Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/23916
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dc.contributor.authorBetancor, Monicaen_UK
dc.contributor.authorSprague, Matthewen_UK
dc.contributor.authorSayanova, Olgaen_UK
dc.contributor.authorUsher, Sarahen_UK
dc.contributor.authorMetochis, Christoforosen_UK
dc.contributor.authorCampbell, Patricken_UK
dc.contributor.authorNapier, Johnathan Aen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.date.accessioned2016-10-20T02:47:44Z-
dc.date.available2016-10-20T02:47:44Z-
dc.date.issued2016-07-25en_UK
dc.identifier.othere0159934en_UK
dc.identifier.urihttp://hdl.handle.net/1893/23916-
dc.description.abstractVegetable oils (VO) are possible substitutes for fish oil in aquafeeds but their use is limited by their lack of omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA). However, oilseed crops can be modified to produce n-3 LC-PUFA such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, representing a potential option to fill the gap between supply and demand of these important nutrients. Camelina sativa was metabolically engineered to produce a seed oil with around 15 % total n-3 LC-PUFA to potentially substitute for fish oil in salmon feeds. Post-smolt Atlantic salmon (Salmo salar) were fed for 11-weeks with one of three experimental diets containing either fish oil (FO), wild-type Camelina oil (WCO) or transgenic Camelina oil (DCO) as added lipid source to evaluate fish performance, nutrient digestibility, tissue n-3 LC-PUFA, and metabolic impact determined by liver transcriptome analysis. The DCO diet did not affect any of the performance or health parameters studied and enhanced apparent digestibility of EPA and DHA compared to the WCO diet. The level of total n-3 LC-PUFA was higher in all the tissues of DCO-fed fish than in WCO-fed fish with levels in liver similar to those in fish fed FO. Endogenous LC-PUFA biosynthetic activity was observed in fish fed both the Camelina oil diets as indicated by the liver transcriptome and levels of intermediate metabolites such as docosapentaenoic acid, with data suggesting that the dietary combination of EPA and DHA inhibited desaturation and elongation activities. Expression of genes involved in phospholipid and triacylglycerol metabolism followed a similar pattern in fish fed DCO and WCO despite the difference in n-3 LC-PUFA contents.en_UK
dc.language.isoenen_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationBetancor M, Sprague M, Sayanova O, Usher S, Metochis C, Campbell P, Napier JA & Tocher DR (2016) Nutritional evaluation of an EPA-DHA oil from transgenic Camelina sativa in feeds for post-smolt Atlantic salmon (Salmo salar L.). PLoS ONE, 11 (7), Art. No.: e0159934. https://doi.org/10.1371/journal.pone.0159934en_UK
dc.rights© 2016 Betancor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleNutritional evaluation of an EPA-DHA oil from transgenic Camelina sativa in feeds for post-smolt Atlantic salmon (Salmo salar L.)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1371/journal.pone.0159934en_UK
dc.identifier.pmid27454884en_UK
dc.citation.jtitlePLoS ONEen_UK
dc.citation.issn1932-6203en_UK
dc.citation.volume11en_UK
dc.citation.issue7en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiomar Ltden_UK
dc.author.emailm.b.betancor@stir.ac.uken_UK
dc.citation.date25/07/2016en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationRothamsted Researchen_UK
dc.contributor.affiliationRothamsted Researchen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationBioMar U.K.en_UK
dc.contributor.affiliationRothamsted Researchen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000381515200058en_UK
dc.identifier.scopusid2-s2.0-84980426599en_UK
dc.identifier.wtid555161en_UK
dc.contributor.orcid0000-0003-1626-7458en_UK
dc.contributor.orcid0000-0002-0723-2387en_UK
dc.contributor.orcid0000-0002-3299-0630en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dc.date.accepted2016-07-11en_UK
dcterms.dateAccepted2016-07-11en_UK
dc.date.filedepositdate2016-07-21en_UK
dc.relation.funderprojectEvaluating novel plant oilseeds enriched in omega-3 long-chain polyunsaturated fatty acids to support sustainable development of aquacultureen_UK
dc.relation.funderrefBB/J001252/1en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorBetancor, Monica|0000-0003-1626-7458en_UK
local.rioxx.authorSprague, Matthew|0000-0002-0723-2387en_UK
local.rioxx.authorSayanova, Olga|en_UK
local.rioxx.authorUsher, Sarah|en_UK
local.rioxx.authorMetochis, Christoforos|0000-0002-3299-0630en_UK
local.rioxx.authorCampbell, Patrick|en_UK
local.rioxx.authorNapier, Johnathan A|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.projectBB/J001252/1|Biomar Ltd|en_UK
local.rioxx.freetoreaddate2016-07-25en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2016-07-25en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2016-07-25|en_UK
local.rioxx.filenamejournal.pone.0159934.PDFen_UK
local.rioxx.filecount1en_UK
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