Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/23259
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (Medulloepithelioma)
Authors: Baily, Johanna
Morrison, Linda R
Patterson, I A
Underwood, Clare
Dagleish, Mark P
Contact Email: j.l.baily@stir.ac.uk
Keywords: central nervous system
neoplasia
primitive neuroectodermal tumour
Stenella coeruleoalba
Issue Date: Nov-2013
Publisher: Elsevier
Citation: Baily J, Morrison LR, Patterson IA, Underwood C & Dagleish MP (2013) Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (Medulloepithelioma), Journal of Comparative Pathology, 149 (4), pp. 514-519.
Abstract: Primary brain tumours in cetaceans are rare with only four reported cases of intracranial tumours in the scientific literature. A juvenile female, striped dolphin live-stranded at Whitepark Bay, Co Antrim, Northern Ireland, UK, and died after an unsuccessful attempt at refloatation. Necropsy examination revealed a large, soft, non-encapsulated friable mass, which expanded and replaced the frontal lobes, corpus callosum and caudate nucleus of the brain and extended into the lateral ventricles, displacing the thalamus caudally. Microscopically, this comprised moderately pleomorphic neoplastic cells arranged variably in dense monotonous sheets, irregular streams, ependymal rosettes, ‘ependymoblastomatous rosettes’ and multilayered to pseudostratified tubules. Liquefactive necrosis, palisading glial cells, haemorrhage and mineralization were also observed. Immunohistochemically, the neoplastic cells expressed vimentin but not S100, glial fibrillary acidic protein, cytokeratin, neuron-specific enolase or synaptophysin. Based on these findings a diagnosis of primitive neuroectodermal tumour was made. Monitoring and recording such cases is crucial as neoplasia may be related to viral, carcinogenic or immunosuppressive chemical exposure and can ultimately contribute to assessing the ocean health.
Type: Journal Article
URI: http://hdl.handle.net/1893/23259
DOI Link: http://dx.doi.org/10.1016/j.jcpa.2013.06.003
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of Edinburgh
Agri-food & Biosciences Institute
The Moredun Research Institute
The Moredun Research Institute

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