Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22906
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The Hippo signal transduction network for exercise physiologists
Authors: Gabriel, Brendan M
Hamilton, David Lee
Tremblay, Annie M
Wackerhage, Henning
Contact Email: d.l.hamilton@stir.ac.uk
Keywords: Exercise
Hippo
Hypertrophy
Skeletal Muscle
Yap
Issue Date: 15-May-2016
Publisher: American Physiological Society
Citation: Gabriel BM, Hamilton DL, Tremblay AM & Wackerhage H (2016) The Hippo signal transduction network for exercise physiologists, Journal of Applied Physiology, 120 (10), pp. 1105-1117.
Abstract: The ubiquitous transcriptional co-activators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by co-activating the Tead transcription factors. Yap and Taz lie at the centre of the Hippo signalling network and are not only regulated by the Hippo kinase cassette itself but also by a plethora of exercise-associated signals and signalling modules. These include mechanotransduction, the AKT-mTORC1 network, SMAD transcription factors, hypoxia, glucose, AMPK, adrenaline/epinephrine and angiotensin II through G protein-coupled receptors, and interleukin 6 (Il-6). Consequently exercise should alter Hippo signalling in several organs to mediate at least some aspects of organ-specific adaptations to exercise. Consistent with this idea Tead1 over expression in muscle fibres has been shown to promote a fast-to-slow fibre type switch whereas Yap in muscle fibres and cardiomyocytes promotes skeletal muscle and cardiac hypertrophy, respectively. Finally TEAD1, YAP1, VGLL2, VGLL3 and VGLL4 have all been linked in genome wide-association studies to body height, a key factor in sports.
Type: Journal Article
URI: http://hdl.handle.net/1893/22906
DOI Link: http://dx.doi.org/10.1152/japplphysiol.01076.2015
Rights: Author's Accepted Manuscript: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Publisher policy allows this work to be made available in this repository. Published in Journal of Applied Physiology by American Physiological Society. The original publication is available at: http://dx.doi.org/10.1152/japplphysiol.01076.2015
Publisher version: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Aberdeen
Sport
Harvard University
University of Aberdeen

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