Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22752
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men
Authors: Cocks, Matthew
Shaw, Christopher S
Shepherd, Sam O
Fisher, James P
Ranasinghe, Aaron M
Barker, Thomas A
Tipton, Kevin
Wagenmakers, Anton J M
Contact Email: k.d.tipton@stir.ac.uk
Keywords: insulin sensitivity
muscle microvascular endothelial function
nitric oxide
NAD(P)Hoxidase
Issue Date: Nov-2014
Publisher: Wiley-Blackwell
Citation: Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe AM, Barker TA, Tipton K & Wagenmakers AJM (2014) Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men, Microcirculation, 21 (8), pp. 738-746.
Abstract: Objective  The effects of RT on muscle mass, strength, and insulin sensitivity are well established, but the underlying mechanisms are only partially understood. The main aim of this study was to investigate whether RT induces changes in endothelial enzymes of the muscle microvasculature, which would increase NO bioavailability and could contribute to improved insulin sensitivity.  Methods  Eight previously sedentary males (age 20±0.4years, BMI 24.5±0.9kg/m2) completed six weeks of RT 3x/week. Muscle biopsies were taken from the m. vastus lateralis and microvascular density; and endothelial-specific eNOS content, eNOS Ser1177phosphorylation, and NOX2 content were assessed pre- and post-RT using quantitative immunofluorescence microscopy. Whole-body insulin sensitivity (measured as Matsuda Index), microvascularKf(functional measure of the total available endothelial surface area), and arterial stiffness (AIx, central, and pPWV) were also measured.  Results  Measures of microvascular density, microvascularKf, microvascular eNOS content, basal eNOS phosphorylation, and endothelial NOX2 content did not change from pre-RT to post-RT. RT increased insulin sensitivity (p<0.05) and reduced resting blood pressure and AIx (p<0.05), but did not change central or pPWV.  Conclusions RT did not change any measure of muscle microvascular structure or function.
Type: Journal Article
URI: http://hdl.handle.net/1893/22752
DOI Link: http://dx.doi.org/10.1111/micc.12155
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Liverpool John Moores University
Victoria University
Liverpool John Moores University
University of Birmingham
University of Birmingham
University of Birmingham
Sport
Liverpool John Moores University

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