Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22751
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effect of Intensive Training on Mood With No Effect on Brain-Derived Neurotrophic Factor
Authors: Piacentini, Maria Francesca
Witard, Oliver
Tonoli, Cajsa
Jackman, Sarah R
Turner, James E
Kies, Arie K
Jeukendrup, Asker E
Tipton, Kevin
Meeusen, Romain
Contact Email: oliver.witard@stir.ac.uk
Keywords: Functional overreaching
psychological mood state
neurotrophins
cortisol
trained cyclists
Issue Date: Sep-2016
Publisher: Human Kinetics
Citation: Piacentini MF, Witard O, Tonoli C, Jackman SR, Turner JE, Kies AK, Jeukendrup AE, Tipton K & Meeusen R (2016) Effect of Intensive Training on Mood With No Effect on Brain-Derived Neurotrophic Factor, International Journal of Sports Physiology and Performance, 11 (6), pp. 824-830.
Abstract: Purpose Monitoring mood state is a useful tool for avoiding non-functional overreaching (NFOR). Brain derived neurotrophic factor (BDNF) is implicated in stress-related mood disorders. The purpose of the present study was to investigate the impact of intensified training-induced mood disturbance on plasma BDNF concentrations at rest and in response to exercise.  Methods Eight cyclists performed 1 week of normal (NT), 1 week of intensified (INT) and 1 week of recovery (REC) training. Fasted blood samples were collected before and after exercise, on day 7 of each training week and were analyzed for plasma BDNF and cortisol concentrations. A 24-item Profile Of Mood State questionnaire was administered on day 7 of each training week and global mood score (GMS) was calculated. Results Time trial performance was impaired during INT (p=0.01) and REC (p=0.02) compared with NT. Basal plasma cortisol (NT=153±16 ng/ml, INT=130±11 ng/ml, REC=150±14 ng/ml) and BDNF (NT=484±122 pg/ml, INT=488±122 pg/ml, REC=383±56 pg/ml) concentrations were similar between training conditions. Likewise, similar exercise-induced increases in cortisol and BDNF concentrations were observed between training conditions. GMS was 32% greater during INTvs.NT (P<0.001). Conclusion Consistent with a state of functional overreaching (FOR), impairments in performance and mood state with INT were restored after one week of REC. These results support evidence that mood changes before plasma BDNF concentrations as a biochemical marker of FOR and that cortisol is not a useful marker for predicting FOR.
Type: Journal Article
URI: http://hdl.handle.net/1893/22751
DOI Link: http://dx.doi.org/10.1123/ijspp.2015-0279
Rights: As accepted for publication in International Journal of Sports Physiology and Performance, ©Human Kinetics DOI: http://dx.doi.org/10.1123/ijsnem.2015-0218
Affiliation: Foro Italico University of Rome
Sport
Vrije Universiteit Brussel
University of Exeter
University of Bath
DSM Food Specialties, Delft, The Netherlands
Gatorade Sports Science Institute
Sport
Vrije Universiteit Brussel

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