Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22728
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?
Authors: Der, Geoff
Batty, G David
Benzeval, Michaela
Deary, Ian
Green, Michael J
McGlynn, Liane M
McIntyre, Alan
Robertson, Tony
Shiels, Paul G
Contact Email: tony.robertson@stir.ac.uk
Keywords: Adolescent
Adult
Aged
Aging
Aging: genetics
Biological Markers
Cognition
Cognition: physiology
Cross-Sectional Studies
Female
Humans
Longitudinal Studies
Male
Middle Aged
Predictive Value of Tests
Principal Component Analysis
Scotland
Telomere
Telomere Homeostasis
Telomere Homeostasis: genetics
Telomere: chemistry
Telomere: genetics
Issue Date: 24-Sep-2012
Publisher: Public Library of Science
Citation: Der G, Batty GD, Benzeval M, Deary I, Green MJ, McGlynn LM, McIntyre A, Robertson T & Shiels PG (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?, PLoS ONE, 7 (9), Art. No.: e45166.
Abstract: BACKGROUND: The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research. This may be because the criteria are too strict or because a composite measure might be more appropriate. Telomere length has attracted a great deal of attention as a candidate BoA. We investigate whether it meets the criteria to be considered as a single biomarker of aging, and whether it makes a useful contribution to a composite measure. METHODOLOGY/PRINCIPAL FINDINGS: Using data from a large population based study, we show that telomere length is associated with age, with several measures of physical and cognitive functioning that are related to normal aging, and with three measures of overall health. In the majority of cases, telomere length adds predictive power to that of age, although it was not nearly as good a predictor overall. We used principal components analysis to form two composites from the measures of functioning, one including telomere length and the other not including it. These composite BoAs were better predictors of the health outcomes than chronological age. There was little difference between the two composites. CONCLUSIONS: Telomere length does not satisfy the strict criteria for a BoA, but does add predictive power to that of chronological age. Equivocal results from previous studies might be due to lack of power or the choice of measures examined together with a focus on single biomarkers. Composite biomarkers of aging have the potential to outperform age and should be considered for future research in this area.
Type: Journal Article
URI: http://hdl.handle.net/1893/22728
DOI Link: http://dx.doi.org/10.1371/journal.pone.0045166
Rights: © Der et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Affiliation: University of Birmingham
University of Edinburgh
University of Glasgow
University of Edinburgh
University of Glasgow
University of Glasgow
University of Glasgow
HS - Management and Support
University of Glasgow

Files in This Item:
File Description SizeFormat 
robertson (2012) plos one - telomere x ses.pdf143.13 kBAdobe PDFView/Open


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.