Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22718
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Long-chain polyunsaturated fatty acid biosynthesis in chordates: insights into the evolution of Fads and Elovl gene repertoire
Authors: Costa, Castro Luıs Filipe
Tocher, Douglas R
Monroig, Oscar
Contact Email: oscar.monroig@stir.ac.uk
Keywords: Chordates
elongation of very long-chain fatty acid protein
evolution
front-end desaturase
long-chain polyunsaturated fatty acids
Issue Date: Apr-2016
Publisher: Elsevier
Citation: Costa Castro LF, Tocher DR & Monroig O (2016) Long-chain polyunsaturated fatty acid biosynthesis in chordates: insights into the evolution of Fads and Elovl gene repertoire, Progress in Lipid Research, 62, pp. 25-40.
Abstract: Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid molecules and are also involved in numerous critical biological processes. Studies conducted mainly in vertebrates have demonstrated that LC-PUFA can be biosynthesized through the concerted action of two sets of enzymes, namely fatty acyl desaturases (Fads) and elongation of very long-chain fatty acid (Elovl) proteins. While LC-PUFA research is a thriving field, mainly focused on human health, an integrated view regarding the evolution of LC-PUFA biosynthetic genetic machinery in chordates is yet to be produced. Particularly important is to understand whether lineage specific life history trajectories, as well as major biological transitions, or particular genomic processes such as genome duplications have impacted the evolution of LC-PUFA biosynthetic pathways. Here we review the gene repertoire of Fads and Elovl in chordate genomes and the diversity of substrate specificities acquired during evolution. We take advantage of the magnitude of genomic and functional data to show that combination duplication processes and functional plasticity have generated a wide diversity of physiological capacities in extant lineages. A clear evolutionary framework is provided, which will be instrumental for the full clarification of functional capacities between the various vertebrate groups.
Type: Journal Article
URI: http://hdl.handle.net/1893/22718
DOI Link: http://dx.doi.org/10.1016/j.plipres.2016.01.001
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Costa Castro LF, Tocher DR & Monroig O (2016) Long-chain polyunsaturated fatty acid biosynthesis in chordates: insights into the evolution of Fads and Elovl gene repertoire, Progress in Lipid Research, 62, pp. 25-40. DOI: 10.1016/j.plipres.2016.01.001 © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Affiliation: University of Porto
Aquaculture
Complex Systems

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