Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22611
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recovery
Authors: Brooks, Naomi
Cadena, Samuel M
Vannier, Edouard
Cloutier, Gregory
Carambula, Silvia
Myburgh, Kathryn H
Roubenoff, Ronenn
Castaneda-Sceppa, Carmen
Contact Email: n.e.brooks@stir.ac.uk
Keywords: bed rest
energy deficit
essential amino acid supplementation
myogenic factors
resistance exercise
Issue Date: Dec-2010
Publisher: Wiley-Blackwell
Citation: Brooks N, Cadena SM, Vannier E, Cloutier G, Carambula S, Myburgh KH, Roubenoff R & Castaneda-Sceppa C (2010) Effects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recovery, Muscle and Nerve, 42 (6), pp. 927-935.
Abstract: Spaceflight and bed rest (BR) lead to muscle atrophy. This study assessed the effect of essential amino acid (EAA) supplementation and resistance training with decreased energy intake on molecular changes in skeletal muscle after 28-day BR and 14-day recovery. Thirty-one men (31-55 years) subjected to an 8 ± 6% energy deficit were randomized to receive EAA without resistance training (AA, n = 7), or EAA 3 h after (RT, n = 12) or 5 min before (AART, n = 12) resistance training. During BR, myostatin transcript levels increased twofold in the AA group. During recovery, insulin-like growth factor-1 (IGF-1) mRNA increased in all groups, whereas Pax7, MyoD, myogenin, and MRF4 transcripts increased in AA only (all P < 0.05). MAFbx transcripts decreased twofold with AA and RT. Satellite cells did not change during BR or recovery. This suggests that EAA alone is the least protective countermeasure to muscle loss, and several molecular mechanisms are proposed by which exercise attenuates muscle atrophy during BR with energy deficit.
Type: Journal Article
URI: http://hdl.handle.net/1893/22611
DOI Link: http://dx.doi.org/10.1002/mus.21780
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Sport
Tufts University
Tufts Medical Center, Boston, USA
Tufts University
Tufts University
University of Stellenbosch, South Africa
Tufts University
Northeastern University (US)

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