Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22576
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dc.contributor.authorCarmona-Antonanzas, Gretaen_UK
dc.contributor.authorCarmichael, Stephen Nen_UK
dc.contributor.authorHeumann, Janen_UK
dc.contributor.authorTaggart, Johnen_UK
dc.contributor.authorBron, Jamesen_UK
dc.contributor.authorBekaert, Michaëlen_UK
dc.contributor.authorSturm, Arminen_UK
dc.contributor.authorGharbi, Karimen_UK
dc.date.accessioned2016-09-06T03:36:33Z-
dc.date.available2016-09-06T03:36:33Z-
dc.date.issued2015-09-29en_UK
dc.identifier.othere0137394en_UK
dc.identifier.urihttp://hdl.handle.net/1893/22576-
dc.description.abstractSalmon lice,Lepeophtheirus salmonis(Krøyer, 1837), are fish ectoparasites causing significant economic damage in the mariculture of Atlantic salmon,Salmo salarLinnaeus, 1758. The control ofL.salmonisat fish farms relies to a large extent on treatment with anti-parasitic drugs. A problem related to chemical control is the potential for development of resistance, which inL.salmonisis documented for a number of drug classes including organophosphates, pyrethroids and avermectins. The ATP-binding cassette (ABC) gene superfamily is found in all biota and includes a range of drug efflux transporters that can confer drug resistance to cancers and pathogens. Furthermore, some ABC transporters are recognised to be involved in conferral of insecticide resistance. While a number of studies have investigated ABC transporters inL.salmonis, no systematic analysis of the ABC gene family exists for this species. This study presents a genome-wide survey of ABC genes inL.salmonisfor which, ABC superfamily members were identified through homology searching of theL.salmonisgenome. In addition, ABC proteins were identified in a reference transcriptome of the parasite generated by high-throughput RNA sequencing (RNA-seq) of a multi-stage RNA library. Searches of both genome and transcriptome allowed the identification of a total of 33 genes / transcripts coding for ABC proteins, of which 3 were represented only in the genome and 4 only in the transcriptome. Eighteen sequences were assigned to ABC subfamilies known to contain drug transporters,i.e. subfamilies B (4 sequences), C (11) and G (2). The results suggest that the ABC gene family ofL.salmonispossesses fewer members than recorded for other arthropods. The present survey of theL.salmonisABC gene superfamily will provide the basis for further research into potential roles of ABC transporters in the toxicity of salmon delousing agents and as potential mechanisms of drug resistance.en_UK
dc.language.isoenen_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationCarmona-Antonanzas G, Carmichael SN, Heumann J, Taggart J, Bron J, Bekaert M, Sturm A & Gharbi K (2015) A survey of the ATP-binding cassette (ABC) gene superfamily in the salmon louse (Lepeophtheirus salmonis). PLoS ONE, 10 (9), Art. No.: e0137394. https://doi.org/10.1371/journal.pone.0137394en_UK
dc.rights© 2015 Carmona-Antoñanzas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleA survey of the ATP-binding cassette (ABC) gene superfamily in the salmon louse (Lepeophtheirus salmonis)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1371/journal.pone.0137394en_UK
dc.identifier.pmid26418738en_UK
dc.citation.jtitlePLoS ONEen_UK
dc.citation.issn1932-6203en_UK
dc.citation.volume10en_UK
dc.citation.issue9en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.author.emailarmin.sturm@stir.ac.uken_UK
dc.citation.date29/09/2015en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000362171400006en_UK
dc.identifier.scopusid2-s2.0-84947901287en_UK
dc.identifier.wtid582928en_UK
dc.contributor.orcid0000-0002-3843-9663en_UK
dc.contributor.orcid0000-0003-3544-0519en_UK
dc.contributor.orcid0000-0002-1206-7654en_UK
dc.contributor.orcid0000-0003-2632-1999en_UK
dc.date.accepted2015-08-17en_UK
dcterms.dateAccepted2015-08-17en_UK
dc.date.filedepositdate2015-12-03en_UK
dc.relation.funderprojectIdentifying molecular determinants of drug susceptibility in salmon lice (Lepeophtheirus salmonis)en_UK
dc.relation.funderrefBB/L022923/1en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorCarmona-Antonanzas, Greta|en_UK
local.rioxx.authorCarmichael, Stephen N|en_UK
local.rioxx.authorHeumann, Jan|en_UK
local.rioxx.authorTaggart, John|0000-0002-3843-9663en_UK
local.rioxx.authorBron, James|0000-0003-3544-0519en_UK
local.rioxx.authorBekaert, Michaël|0000-0002-1206-7654en_UK
local.rioxx.authorSturm, Armin|0000-0003-2632-1999en_UK
local.rioxx.authorGharbi, Karim|en_UK
local.rioxx.projectBB/L022923/1|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.freetoreaddate2015-12-03en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2015-12-03|en_UK
local.rioxx.filenameCarmona-Antonanzas et al_PlosOne_2015.pdfen_UK
local.rioxx.filecount1en_UK
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