Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22328
Appears in Collections:Computing Science and Mathematics eTheses
Title: A Novel Ontology and Machine Learning Driven Hybrid Clinical Decision Support Framework for Cardiovascular Preventative Care
Authors: Farooq, Kamran
Supervisor(s): Hussain, Amir
Keywords: Cardiovascular Clinical Decision Support Framework
Ontology and Machine Learnign Driven Hybrid Clinical Decision Support
Hybrid Clinical Decision Support Framework
Issue Date: 31-Mar-2015
Publisher: University of Stirling
Citation: Kamran Farooq, Amir Hussain, Warner Slack and Bin Luo: An Ontology and Machine Learning Driven Hybrid Cardiovascular Decision Support Framework. IEEE SSCI, Cape Town, December 2015
Kamran Farooq, Jan Karasek, Hicham Atassi, Amir Hussain, Peipei Yang, Calum MacRae, Chris Eckl, Warner Slack and Bin Luo: A Novel Cardiovascular Decision Support Framework for Effective Clinical Risk Assessment. IEEE SSCI, Orlando 2014: 14925.
Kamran Farooq, Peipei Yang, Amir Hussain, Kaizhu Huang, Chris Eckl, Calum MacRae, Warner Slack: Efficient Clinical Decision Making by learning from missing Clinical Data. IEEE SSCI, Singapore 2013: p1024. (Nominated for the best paper award).
Kamran Farooq, Amir Hussain, Stephen Leslie, Chris Eckl, Warner Slack: Ontology-driven cardiovascular decision support system. Pervasive Health 2011: 283-286.
Kamran Farooq, Amir Hussain, Hicham Atassi, Stephen Leslie, Chris Eckl, Calum MacRae, Warner Slack- A Novel Clinical Expert System for Chest Pain Risk Assessment. BICS, Beijing, June 2013.
Kamran Farooq, Amir Hussain, Stephen Leslie, Chris Eckl, Calum MacRae, Warner Slack: An Ontology Driven and Bayesian Network Based Cardiovascular Decision Support Framework. BICS 2012: 31-41
Kamran Farooq, Amir Hussain, Stephen Leslie, Chris Eckl, Calum MacRae, Warner Slack: Semantically Inspired Electronic Healthcare Records. BICS 2012: 42-51.
Abstract: Clinical risk assessment of chronic illnesses is a challenging and complex task which requires the utilisation of standardised clinical practice guidelines and documentation procedures in order to ensure consistent and efficient patient care. Conventional cardiovascular decision support systems have significant limitations, which include the inflexibility to deal with complex clinical processes, hard-wired rigid architectures based on branching logic and the inability to deal with legacy patient data without significant software engineering work. In light of these challenges, we are proposing a novel ontology and machine learning-driven hybrid clinical decision support framework for cardiovascular preventative care. An ontology-inspired approach provides a foundation for information collection, knowledge acquisition and decision support capabilities and aims to develop context sensitive decision support solutions based on ontology engineering principles. The proposed framework incorporates an ontology-driven clinical risk assessment and recommendation system (ODCRARS) and a Machine Learning Driven Prognostic System (MLDPS), integrated as a complete system to provide a cardiovascular preventative care solution. The proposed clinical decision support framework has been developed under the close supervision of clinical domain experts from both UK and US hospitals and is capable of handling multiple cardiovascular diseases. The proposed framework comprises of two novel key components: (1) ODCRARS (2) MLDPS. The ODCRARS is developed under the close supervision of consultant cardiologists Professor Calum MacRae from Harvard Medical School and Professor Stephen Leslie from Raigmore Hospital in Inverness, UK. The ODCRARS comprises of various components, which include: (a) Ontology-driven intelligent context-aware information collection for conducting patient interviews which are driven through a novel clinical questionnaire ontology. (b) A patient semantic profile, is generated using patient medical records which are collated during patient interviews (conducted through an ontology-driven context aware adaptive information collection component). The semantic transformation of patients’ medical data is carried out through a novel patient semantic profile ontology in order to give patient data an intrinsic meaning and alleviate interoperability issues with third party healthcare systems. (c) Ontology driven clinical decision support comprises of a recommendation ontology and a NICE/Expert driven clinical rules engine. The recommendation ontology is developed using clinical rules provided by the consultant cardiologist from the US hospital. The recommendation ontology utilises the patient semantic profile for lab tests and medication recommendation. A clinical rules engine is developed to implement a cardiac risk assessment mechanism for various cardiovascular conditions. The clinical rules engine is also utilised to control the patient flow within the integrated cardiovascular preventative care solution. The machine learning-driven prognostic system is developed in an iterative manner using state of the art feature selection and machine learning techniques. A prognostic model development process is exploited for the development of MLDPS based on clinical case studies in the cardiovascular domain. An additional clinical case study in the breast cancer domain is also carried out for the development and validation purposes. The prognostic model development process is general enough to handle a variety of healthcare datasets which will enable researchers to develop cost effective and evidence based clinical decision support systems. The proposed clinical decision support framework also provides a learning mechanism based on machine learning techniques. Learning mechanism is provided through exchange of patient data amongst the MLDPS and the ODCRARS. The machine learning-driven prognostic system is validated using Raigmore Hospital's RACPC, heart disease and breast cancer clinical case studies.
Type: Thesis or Dissertation
URI: http://hdl.handle.net/1893/22328

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