Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21949
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Nutrigenomic profiling of transcriptional processes affected in liver and distal intestine in response to a soybean meal-induced nutritional stress in Atlantic salmon (Salmo salar)
Authors: De, Santis Christian
Bartie, Kerry
Olsen, Rolf E
Taggart, John
Tocher, Douglas R
Contact Email: drt1@stir.ac.uk
Keywords: dietary protein substitution
transcriptome
liver
intestine
Atlantic salmon
Salmo salar
soybean meal
nutrigenomic
Issue Date: Sep-2015
Publisher: Elsevier
Citation: De Santis C, Bartie K, Olsen RE, Taggart J & Tocher DR (2015) Nutrigenomic profiling of transcriptional processes affected in liver and distal intestine in response to a soybean meal-induced nutritional stress in Atlantic salmon (Salmo salar), Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 15, pp. 1-11.
Abstract: The aim of the present study was to generate an experimental model to characterize the nutrigenomic profile of a plant-derived nutritional stress. Atlantic salmon (Salmo salar) was used as the model species and the nutritional stress was induced by inclusion of dietary defatted soybean meal (SBM), as this ingredient had been previously demonstrated to induce enteropathy in the distal intestine and reduced growth performance in salmon. Triplicate groups of Atlantic salmon were fed increasing concentrations (0, 100, 200 and 300 g kg-1) of SBM for 12 weeks and reduced growth performance was used as the indicator of nutritional stress. The transcriptome was analysed in two tissues, distal intestine and liver, with the hypothesis being that intestinal gene expression would be dominated by specific responses to SBM whereas the liver transcriptome would include gene expression responses that could be more general and related to overall performance. Specifically, a set of 133 genes was differentially expressed in liver including 45 genes in common with the intestinal response. The liver specific response included genes involved in protein digestion and energy metabolism that were up-regulated, whereas genes in other pathways were generally anabolic and down-regulated. These responses may be more related to general nutritional stress than to SBM per se. This study provides a comprehensive report on the profiles of distal intestine and liver transcriptomes, highlighting the role of the latter tissue in fish undergoing SBM-induced nutritional stress.
Type: Journal Article
URI: http://hdl.handle.net/1893/21949
DOI Link: http://dx.doi.org/10.1016/j.cbd.2015.04.001
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: De Santis C, Bartie K, Olsen RE, Taggart J & Tocher DR (2015) Nutrigenomic profiling of transcriptional processes affected in liver and distal intestine in response to a soybean meal-induced nutritional stress in Atlantic salmon (Salmo salar), Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 15, pp. 1-11. DOI: 10.1016/j.cbd.2015.04.001 © 2015, Elsevier. Licensed under the Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Affiliation: Aquaculture
Aquaculture
Matre Aquaculture Research Station
Aquaculture
Aquaculture

Files in This Item:
File Description SizeFormat 
DeSantis et al (AquaeexcelSBM)CBP.pdf1.58 MBAdobe PDFView/Open


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.