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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish
Authors: Betancor, Monica
Sprague, Matthew
Usher, Sarah
Sayanova, Olga
Campbell, Patrick
Napier, Johnathan A
Tocher, Douglas R
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Keywords: molecular engineering in plants
fatty acids
Issue Date: 29-Jan-2015
Publisher: Nature Group
Citation: Betancor M, Sprague M, Usher S, Sayanova O, Campbell P, Napier JA & Tocher DR (2015) A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish, Scientific Reports, 5, Art. No.: 8104.
Abstract: For humans a daily intake of up to 500mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric tonnes (mt) for a population of 7 billion people. The annual global supply of n-3 LC-PUFA cannot meet this level of requirement and so there is a large gap between supply and demand. The dietary source of n-3 LC-PUFA, fish and seafood, is increasingly provided by aquaculture but using fish oil in feeds to supply n-3 LC-PUFA is unsustainable. Therefore, new sources of n-3 LC-PUFA are required to supply the demand from aquaculture and direct human consumption. One approach is metabolically engineering oilseed crops to synthesize n-3 LC-PUFA in seeds. Transgenic Camelina sativa expressing algal genes was used to produce an oil containing n-3 LC-PUFA to replace fish oil in salmon feeds. The oil had no detrimental effects on fish performance, metabolic responses or the nutritional quality of the fillets of the farmed fish.
Type: Journal Article
DOI Link:
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit
Affiliation: Aquaculture
Rothamsted Research
Rothamsted Research
BioMar U.K.
Rothamsted Research

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