Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21411
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules
Authors: Garcia-Valtanen, Pablo
Ortega-Villaizan, Maria del Mar
Martinez-Lopez, Alicia
Medina-Gali, Regla
Perez, Luis
MacKenzie, Simon
Figueras, Antonio
Coll, Julio M
Estepa, Amparo
Contact Email: simon.mackenzie@stir.ac.uk
Keywords: antiviral
autophagy
immune response
LC3
microarrays
pepscan
rhabdovirus
SVCV
VHSV
viral glycoprotein
VSV
zebrafish
Issue Date: Sep-2014
Publisher: Taylor and Francis
Citation: Garcia-Valtanen P, Ortega-Villaizan MdM, Martinez-Lopez A, Medina-Gali R, Perez L, MacKenzie S, Figueras A, Coll JM & Estepa A (2014) Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules, Autophagy, 10 (9), pp. 1666-1680.
Abstract: It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish (viral hemorrhagic septicemia virus, VHSV, and spring viremia carp virus, SVCV) rhabdoviral Gs induce an autophagic antiviral program in vertebrate cell lines. The transcriptomic profiles obtained from zebrafish genetically immunized with either Gsvcv or Gvhsv suggest that autophagy is induced shortly after immunization and therefore, it may be an important component of the strong antiviral immune responses elicited by these viral proteins. Pepscan mapping of autophagy-inducing linear determinants of Gvhsv and Gvsv showed that peptides located in their fusion domains induce autophagy. Altogether these results suggest that strategies aimed at modulating autophagy could be used for the prevention and treatment of rhabdoviral infections such as rabies, which causes thousands of human deaths every year.
Type: Journal Article
URI: http://hdl.handle.net/1893/21411
DOI Link: http://dx.doi.org/10.4161/auto.29557
Rights: Copyright © 2014 Landes Bioscience This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Permission is granted subject to the terms of the License under which the work was published. Please check the License conditions for the work which you wish to reuse. Full and appropriate attribution must be given. This permission does not cover any third party copyrighted material which may appear in the work requested.
Affiliation: The Miguel Hernandez University of Elche
The Miguel Hernandez University of Elche
The Miguel Hernandez University of Elche
Labiofam
The Miguel Hernandez University of Elche
Complex Systems
Spanish National Research Council (CSIC)
INIA-SIGT–Biotecnologia
The Miguel Hernandez University of Elche

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