Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21101
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dc.contributor.authorSenis, Yotis Aen_UK
dc.contributor.authorTomlinson, Michael Gen_UK
dc.contributor.authorEllison, Stuarten_UK
dc.contributor.authorMazharian, Alexandraen_UK
dc.contributor.authorLim, Jensonen_UK
dc.contributor.authorZhao, Yanen_UK
dc.contributor.authorKornerup, Kristin Nen_UK
dc.contributor.authorAuger, Jocelyn Men_UK
dc.contributor.authorThomas, Steve Gen_UK
dc.contributor.authorDhanjal, Tarvinderen_UK
dc.contributor.authorKalia, Neenaen_UK
dc.contributor.authorZhu, Jing Wen_UK
dc.contributor.authorWeiss, Arthuren_UK
dc.contributor.authorWatson, Steve Pen_UK
dc.date.accessioned2014-09-17T23:12:06Z-
dc.date.available2014-09-17T23:12:06Zen_UK
dc.date.issued2009-05en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21101-
dc.description.abstractPlatelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation at sites of vascular injury are regulated by a diverse repertoire of tyrosine kinase-linked and G protein-coupled receptors. Src family kinases (SFKs) play a central role in initiating and propagating signaling from several platelet surface receptors; however, the underlying mechanism of how SFK activity is regulated in platelets remains unclear. CD148 is the only receptor-like protein tyrosine phosphatase identified in platelets to date. In the present study, we show that mutant mice lacking CD148 exhibited a bleeding tendency and defective arterial thrombosis. Basal SFK activity was found to be markedly reduced in CD148-deficient platelets, resulting in a global hyporesponsiveness to agonists that signal through SFKs, including collagen and fibrinogen. G protein-coupled receptor responses to thrombin and other agonists were also marginally reduced. These results highlight CD148 as a global regulator of platelet activation and a novel antithrombotic drug target.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Society of Hematologyen_UK
dc.relationSenis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A & Watson SP (2009) The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood, 113 (20), pp. 4942-4954. https://doi.org/10.1182/blood-2008-08-174318en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleThe tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Senis_Watson_Blood_2009.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1182/blood-2008-08-174318en_UK
dc.citation.jtitleBlooden_UK
dc.citation.issn1528-0020en_UK
dc.citation.issn0006-4971en_UK
dc.citation.volume113en_UK
dc.citation.issue20en_UK
dc.citation.spage4942en_UK
dc.citation.epage4954en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailjenson.lim@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of California, San Franciscoen_UK
dc.contributor.affiliationUniversity of California, San Franciscoen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000266090700020en_UK
dc.identifier.scopusid2-s2.0-66549093856en_UK
dc.identifier.wtid622310en_UK
dc.contributor.orcid0000-0001-7417-356Xen_UK
dcterms.dateAccepted2009-05-31en_UK
dc.date.filedepositdate2014-09-17en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorSenis, Yotis A|en_UK
local.rioxx.authorTomlinson, Michael G|en_UK
local.rioxx.authorEllison, Stuart|en_UK
local.rioxx.authorMazharian, Alexandra|en_UK
local.rioxx.authorLim, Jenson|0000-0001-7417-356Xen_UK
local.rioxx.authorZhao, Yan|en_UK
local.rioxx.authorKornerup, Kristin N|en_UK
local.rioxx.authorAuger, Jocelyn M|en_UK
local.rioxx.authorThomas, Steve G|en_UK
local.rioxx.authorDhanjal, Tarvinder|en_UK
local.rioxx.authorKalia, Neena|en_UK
local.rioxx.authorZhu, Jing W|en_UK
local.rioxx.authorWeiss, Arthur|en_UK
local.rioxx.authorWatson, Steve P|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameSenis_Watson_Blood_2009.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0006-4971en_UK
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