|Appears in Collections:||Biological and Environmental Sciences Book Chapters and Sections|
|Title:||Small GTP Binding Proteins and the Control of Phagocytic Uptake|
|Citation:||Wiedemann A, Lim J & Caron E (2005) Small GTP Binding Proteins and the Control of Phagocytic Uptake. In: Molecular Mechanisms of Phagocytosis. Medical Intelligence Unit, New York: Landes Bioscience/Springer Science, pp. 72-84.|
|Publisher:||Landes Bioscience/Springer Science|
|Series/Report no.:||Medical Intelligence Unit|
|Abstract:||Phagocytosis is a conserved cellular process in Eukaryotes. A multi-step process, it involves the recognition of paniculate material, e.g., microbes and apoptotic cells, their F-actin-driven engulfment and the subsequent destruction of the phagocytized material in phagolysosomes. Distinct sets of small GTP-binding proteins (Rap1, Arf6, Rho and Rab proteins) control and coordinate the successive steps of the phagocytic process. Moreover, these proteins are often targeted by microbial virulence factors. This review summarizes and discusses the evidence implicating Ras, Rho, Arf and Rab-family GTPases in the signalling pathways driving particle recognition and uptake.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Type:||Part of book or chapter of book|
|Affiliation:||Imperial College London|
Biological and Environmental Sciences
Imperial College London
|2004 Wiedermann et al review phagocytosis GTPases.pdf||154.28 kB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
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