Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20674
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dc.contributor.authorBrooks, Naomien_UK
dc.contributor.authorMyburgh, Kathryn Hen_UK
dc.date.accessioned2018-01-09T04:14:45Z-
dc.date.available2018-01-09T04:14:45Z-
dc.date.issued2014-03-17en_UK
dc.identifier.other99en_UK
dc.identifier.urihttp://hdl.handle.net/1893/20674-
dc.description.abstractMaintenance of skeletal muscle is essential for health and survival. There are marked losses of skeletal muscle mass as well as strength and physiological function under conditions of low mechanical load, such as space flight, as well as ground based models such as bed rest, immobilization, disuse, and various animal models. Disuse atrophy is caused by mechanical unloading of muscle and this leads to reduced muscle mass without fiber attrition. Skeletal muscle stem cells (satellite cells) and myonuclei are integrally involved in skeletal muscle responses to environmental changes that induce atrophy. Myonuclear domain size is influenced differently in fast and slow twitch muscle, but also by different models of muscle wasting, a factor that is not yet understood. Although the myonuclear domain is 3-dimensional this is rarely considered. Apoptosis as a mechanism for myonuclear loss with atrophy is controversial, whereas cell death of satellite cells has not been considered. Molecular signals such as myostatin/SMAD pathway, MAFbx, and MuRF1 E3 ligases of the ubiquitin proteasome pathway and IGF1-AKT-mTOR pathway are 3 distinctly different contributors to skeletal muscle protein adaptation to disuse. Molecular signaling pathways activated in muscle fibers by disuse are rarely considered within satellite cells themselves despite similar exposure to unloading or low mechanical load. These molecular pathways interact with each other during atrophy and also when various interventions are applied that could alleviate atrophy. Re-applying mechanical load is an obvious method to restore muscle mass, however how nutrient supplementation (e.g., amino acids) may further enhance recovery (or reduce atrophy despite unloading or ageing) is currently of great interest. Satellite cells are particularly responsive to myostatin and to growth factors. Recently, the hibernating squirrel has been identified as an innovative model to study resistance to atrophy.en_UK
dc.language.isoenen_UK
dc.publisherFrontiers Mediaen_UK
dc.relationBrooks N & Myburgh KH (2014) Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways. Frontiers in Physiology, 5, Art. No.: 99. https://doi.org/10.3389/fphys.2014.00099en_UK
dc.rights© 2014 Brooks and Myburgh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_UK
dc.subjectskeletal muscle atrophyen_UK
dc.subjectmuscle cell signalingen_UK
dc.subjectmyostatinen_UK
dc.subjectMuRF1en_UK
dc.subjectMAFbxen_UK
dc.subjectIGF1-AKT-mTORen_UK
dc.subjectunloadingen_UK
dc.subjectresistance exerciseen_UK
dc.titleSkeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathwaysen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.3389/fphys.2014.00099en_UK
dc.identifier.pmid24672488en_UK
dc.citation.jtitleFrontiers in Physiologyen_UK
dc.citation.issn1664-042Xen_UK
dc.citation.volume5en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailn.e.brooks@stir.ac.uken_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Stellenbosch, South Africaen_UK
dc.identifier.isiWOS:000346840200001en_UK
dc.identifier.scopusid2-s2.0-84897930723en_UK
dc.identifier.wtid626180en_UK
dc.contributor.orcid0000-0002-0269-3475en_UK
dcterms.dateAccepted2014-03-17en_UK
dc.date.filedepositdate2014-07-22en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorBrooks, Naomi|0000-0002-0269-3475en_UK
local.rioxx.authorMyburgh, Kathryn H|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2014-07-22en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/3.0/|2014-07-22|en_UK
local.rioxx.filenamefphys-05-00099.pdfen_UK
local.rioxx.filecount1en_UK
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