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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA
Authors: Kuhn, Jens H
Bao, Yiming
Bavari, Sina
Becker, Stephan
Bradfute, Steven
Brauburger, Kristina
Brister, J Rodney
Bukreyev, Alexander A
Cai, Yingyun
Chandran, Kartik
Davey, Robert A
Dolnik, Olga
Dye, John M
Enterlein, Sven
Weidmann, Manfred
Contact Email:
Issue Date: May-2014
Publisher: Springer
Citation: Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brauburger K, Brister JR, Bukreyev AA, Cai Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S & Weidmann M (2014) Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA, Archives of Virology, 159 (5), pp. 1229-1237.
Abstract: Specific alterations (mutations, deletions, insertions) of virus genomes are crucial for the functional characterization of their regulatory elements and their expression products, as well as a prerequisite for the creation of attenuated viruses that could serve as vaccine candidates. Virus genome tailoring can be performed either by using traditionally cloned genomes as starting materials, followed by site-directed mutagenesis, or by de novo synthesis of modified virus genomes or parts thereof. A systematic nomenclature for such recombinant viruses is necessary to set them apart from wild-type and laboratory-adapted viruses, and to improve communication and collaborations among researchers who may want to use recombinant viruses or create novel viruses based on them. A large group of filovirus experts has recently proposed nomenclatures for natural and laboratory animal-adapted filoviruses that aim to simplify the retrieval of sequence data from electronic databases. Here, this work is extended to include nomenclature for filoviruses obtained in the laboratory via reverse genetics systems. The previously developed template for natural filovirus genetic variant naming, (/)///-, is retained, but we propose to adapt the type of information added to each field for cDNA clone-derived filoviruses. For instance, the full-length designation of an Ebola virus Kikwit variant rescued from a plasmid developed at the US Centers for Disease Control and Prevention could be akin to "Ebola virus H.sapiens-rec/COD/1995/Kikwit-abc1" (with the suffix "rec" identifying the recombinant nature of the virus and "abc1" being a placeholder for any meaningful isolate designator). Such a full-length designation should be used in databases and the methods section of publications. Shortened designations (such as "EBOV") and abbreviations (such as "EBOV/Kik-abc1") could be used in the remainder of the text, depending on how critical it is to convey information contained in the full-length name. "EBOV" would suffice if only one EBOV strain/variant/isolate is addressed.
Type: Journal Article
DOI Link:
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Notes: Additional authors: Jean-Paul Gonzalez, Pierre Formenty, Alexander N. Freiberg, Lisa E. Hensley, Thomas Hoenen, Anna N. Honko, Georgy M. Ignatyev, Peter B. Jahrling, Karl M. Johnson, Hans-Dieter Klenk, Gary Kobinger, Matthew G. Lackemeyer, Eric M. Leroy, Mark S. Lever, Elke Mühlberger, Sergey V. Netesov, Gene G. Olinger, Gustavo Palacios, Jean L. Patterson, Janusz T. Paweska, Louise Pitt, Sheli R. Radoshitzky, Elena I. Ryabchikova, Erica Ollmann Saphire, Aleksandr M. Shestopalov, Sophie J. Smither, Nancy J. Sullivan, Robert Swanepoel, Ayato Takada, Jonathan S. Towner, Guido van der Groen, Viktor E. Volchkov, Valentina A. Volchkova, Victoria Wahl-Jensen, Travis K. Warren, Kelly L. Warfield, Stuart T. Nichol
Affiliation: National Institutes of Health (US)
National Institutes of Health (US)
United States (US) Army - Medical Research Institute of Infectious Diseases
Philipps-Universitat, Germany
University of New Mexico, USA
Boston University
National Institutes of Health (US)
University of Texas Medical Branch
National Institutes of Health (US)
Albert Einstein College of Medicine of Yeshiva University
Texas Biomedical Research Institute
Philipps-Universitat, Germany
United States (US) Army - Medical Research Institute of Infectious Diseases
Integrated BioTherapeutics Inc

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