Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20612
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin
Authors: Lucas-Sanchez, Alejandro
Almaida, Pedro
Martinez-Nicolas, Antonio
Madrid, Juan Antonio
Mendiola, Pilar
de, Costa Jorge
Contact Email: pedro.almaida@stir.ac.uk
Keywords: Circadian system
Aging
Rest-activity rhythms
Sleep
Melatonin
Nothobranchius
Issue Date: May-2013
Publisher: Elsevier
Citation: Lucas-Sanchez A, Almaida P, Martinez-Nicolas A, Madrid JA, Mendiola P & de Costa J (2013) Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin, Experimental Gerontology, 48 (5), pp. 507-516.
Abstract: Adult (48-week-old) and senescent (72-week-old) individually-kept Nothobranchius korthausae were used as experimental subjects to characterise circadian system (CS) function and age-related changes in senescent fish. This species was specifically chosen because it has already shown potential for use as a model system in gerontological studies. The rest-activity rhythm (RAR) in fish can be easily monitored and used to characterise the state of the CS, and it has also been proposed as a reliable model to study sleep-like periods in fish. As they aged, N. korthausae experienced a significant decrease in total daily activity and a progressive impairment of the RAR, accompanied by changes in the regularity, fragmentation and amplitude of the rhythm. The ability of the CS to oscillate autonomously when the two main synchronizers, photoperiod and feeding time, were absent (continuous darkness and random feeding), was also impaired with age, as the capacity to re-synchronise to the light-dark (LD) cycle declined. Melatonin treatment improved the regularity, fragmentation and amplitude of the RAR in senescent fish, and it also improved sleep efficiency. In conclusion, N. korthausae represents a viable model for studying the aging of the circadian system and the restorative effect of chronobiotic substances, such as melatonin.
Type: Journal Article
URI: http://hdl.handle.net/1893/20612
DOI Link: http://dx.doi.org/10.1016/j.exger.2013.02.026
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Murcia
Aquaculture
University of Murcia
University of Murcia
University of Murcia
University of Murcia

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