Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20595
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Changes in mitochondrial membrane composition and oxidative status during rapid growth, maturation and aging in zebrafish, Danio rerio
Authors: Almaida, Pedro
Lucas-Sanchez, Alejandro
Tocher, Douglas R
Contact Email: pedro.almaida@stir.ac.uk
Keywords: Aging
Cardiolipin
Fatty acid
Mitochondrion
Danio rerio
Oxidative stress
Issue Date: Jul-2014
Publisher: Elsevier
Citation: Almaida P, Lucas-Sanchez A & Tocher DR (2014) Changes in mitochondrial membrane composition and oxidative status during rapid growth, maturation and aging in zebrafish, Danio rerio, Biochimica et Biophysica Acta (BBA)- Molecular and Cell Biology of Lipids, 1841 (7), pp. 1003-1011.
Abstract: Considering membranes and membrane components as possible pacemakers of the main processes taking place inside mitochondria, changes in phospholipids or fatty acids could play a central role linking different mechanisms involved in cumulative damage to cell molecules and dysfunction during periods of high stress, such as rapid growth and aging. Changes affecting either lipid class or fatty acid compositions could affect phospholipid and membrane properties and alter mitochondrial function and cell viability. In the present study, mitochondrial oxidative status and mitochondrial membrane phospholipid compositions were analyzed throughout the life-cycle of zebrafish. TBARS content significantly increased in 18-month-old fish while aconitase activity decreased in 24-month-old fish, which have been related with oxidative damage to molecules. Mitochondria-specific superoxide dismutase decreased in 24-month-old animals although this change was not statistically significant. Age affected both mitochondrial phospholipid content and the peroxidation index of most phospholipid classes suggesting that oxidative damage to mitochondrial lipids was occurring.
Type: Journal Article
URI: http://hdl.handle.net/1893/20595
DOI Link: http://dx.doi.org/10.1016/j.bbalip.2014.04.004
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of Murcia
Aquaculture

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