Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19925
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dc.contributor.authorBetancor, Monicaen_UK
dc.contributor.authorCaballero, Maria Joseen_UK
dc.contributor.authorBenitez-Santana, Tibiabinen_UK
dc.contributor.authorSaleh, Redaen_UK
dc.contributor.authorRoo, Javieren_UK
dc.contributor.authorAtalah, Eyaden_UK
dc.contributor.authorIzquierdo, Marisol Sen_UK
dc.date.accessioned2014-04-25T23:22:12Z-
dc.date.available2014-04-25T23:22:12Zen_UK
dc.date.issued2013-05en_UK
dc.identifier.urihttp://hdl.handle.net/1893/19925-
dc.description.abstractIn previous studies, we observed dystrophic alterations in muscle of 48-day-old sea bass fed imbalanced docosahexaenoic acid (DHA) and vitamin E diets. To understand the whole pathological process associated with oxidative stress, a histological study was performed by feeding 14-day-old sea bass larvae with microdiets containing different ratios of DHA/vitamin E (1/150, 5/150 and 5/300) for a period of 21 days. Larvae fed diet 1/150 showed no lesions in contrast to larvae fed diets 5/150 and 5/300 where the highest incidence of muscle lesions and thiobarbituric acid reactive substances (TBARS) content was observed. Semithin sections revealed focal lesions consisting of degenerated fibres with hypercontracted myofilaments and extensive sarcoplasm vacuolization affecting both red and white muscle. Ultrathin sections of degenerating muscle fibres showed diffuse dilatation of sarcoplasmic reticulum, disorganized myofilaments and autophagic vacuoles containing myelin figures and dense bodies. Additionally, some macrophages were observed among injured fibres as numerous satellite cells. Results from the study agree with those obtained from previous work, proving the pathological potential of free radicals in sea bass larvae musculature. Moreover, high vitamin E inclusion could not completely protect cell membranes from free radicals action.en_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwellen_UK
dc.relationBetancor M, Caballero MJ, Benitez-Santana T, Saleh R, Roo J, Atalah E & Izquierdo MS (2013) Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA. Journal of Fish Diseases, 36 (5), pp. 453-465. https://doi.org/10.1111/j.1365-2761.2012.01447.xen_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectdocosahexaenoic aciden_UK
dc.subjectlarvaeen_UK
dc.subjectmuscle dystrophyen_UK
dc.subjectoxidative stressen_UK
dc.subjectsea bassen_UK
dc.subjectultrastructureen_UK
dc.titleOxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHAen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Oxidative status.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1111/j.1365-2761.2012.01447.xen_UK
dc.citation.jtitleJournal of Fish Diseasesen_UK
dc.citation.issn1365-2761en_UK
dc.citation.issn0140-7775en_UK
dc.citation.volume36en_UK
dc.citation.issue5en_UK
dc.citation.spage453en_UK
dc.citation.epage465en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailm.b.betancor@stir.ac.uken_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.identifier.isiWOS:000317484500001en_UK
dc.identifier.scopusid2-s2.0-84876077154en_UK
dc.identifier.wtid638606en_UK
dc.contributor.orcid0000-0003-1626-7458en_UK
dcterms.dateAccepted2013-05-31en_UK
dc.date.filedepositdate2014-04-25en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorBetancor, Monica|0000-0003-1626-7458en_UK
local.rioxx.authorCaballero, Maria Jose|en_UK
local.rioxx.authorBenitez-Santana, Tibiabin|en_UK
local.rioxx.authorSaleh, Reda|en_UK
local.rioxx.authorRoo, Javier|en_UK
local.rioxx.authorAtalah, Eyad|en_UK
local.rioxx.authorIzquierdo, Marisol S|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameOxidative status.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0140-7775en_UK
Appears in Collections:Aquaculture Journal Articles

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