Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19814
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Age-related changes in mitochondrial membrane composition of Nothobranchius rachovii
Authors: Lucas-Sanchez, Alejandro
Almaida, Pedro
Tocher, Douglas R
Mendiola, Pilar
de, Costa Jorge
Contact Email: drt1@stir.ac.uk
Keywords: Aging
Mitochondria
Phospholipid
Fatty acid
Fish
Issue Date: Feb-2014
Publisher: Oxford University Press
Citation: Lucas-Sanchez A, Almaida P, Tocher DR, Mendiola P & de Costa J (2014) Age-related changes in mitochondrial membrane composition of Nothobranchius rachovii, Journals of Gerontology, Series A, 69 A (2), pp. 142-151.
Abstract: Mitochondrial membrane composition may be a critical factor in the mechanisms of the aging process by influencing the propagation of reactions involved in mitochondrial function during periods of high stress. Changes affecting either lipid class or fatty acid compositions could affect phospholipid properties and alter mitochondrial function and cell viability. In the present study, mitochondrial membrane phospholipid compositions were analyzed throughout the life cycle of Nothobranchius rachovii. Mitochondrial phospholipids showed several changes with age. Proportions of cardiolipin decreased and those of sphingomyelin increased between 11- and 14-month-old fish. Fatty acid compositions of indi- vidual phospholipids in mitochondria were also significantly affected with age. These data suggest increasing damage to mitochondrial lipids during the life cycle of N. rachovii that could be one of the main factors related with and contributing to degraded mitochondrial function associated with the aging process.
Type: Journal Article
URI: http://hdl.handle.net/1893/19814
DOI Link: http://dx.doi.org/10.1093/gerona/glt066
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Murcia
Aquaculture
Aquaculture
University of Murcia
University of Murcia

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