Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19669
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dc.contributor.authorSanchez-Vazquez, F Javieren_UK
dc.contributor.authorTerry, Marta Ien_UK
dc.contributor.authorFelizardo, Viviane Oen_UK
dc.contributor.authorVera, LMen_UK
dc.date.accessioned2014-03-28T23:37:36Z-
dc.date.available2014-03-28T23:37:36Zen_UK
dc.date.issued2011-03en_UK
dc.identifier.urihttp://hdl.handle.net/1893/19669-
dc.description.abstractAlthough the chronotoxicity of xenobiotics is relatively well known in mammals, the existence of daily rhythms of drug toxicity and effectiveness in fish has been neglected to date. The aim of this research was to investigate the influence of the time (middle of the light phase [ML] versus middle of the dark phase [MD]) of exposure to two anesthetic substances (MS-222 or clove oil) commonly used with fish on the median lethal concentration (LC50) and swimming activity of zebrafish (Danio rerio). To this end, adult zebrafish were kept under a 12 h:12 h light-dark (LD) cycle and exposed to different concentrations of the anesthetics for 15 min at ML or MD. LC50 calculations were performed using the Spearman-Karber program, whereas swimming activity was video-recorded and analyzed with specialized software. Zebrafish exhibited a mostly diurnal activity pattern (77.9% of activity occurring during daytime). The acute toxicity and mortality caused by MS-222 and eugenol varied with the time of exposure. For MS-222, the LC50 was 170.6 ± 7.4 mg/L in fish exposed at ML and 215.6 ± 3.9 mg/L at MD, whereas for eugenol the LC50 was 70.3 ± 3.1 mg/L at ML and 104.9 ± 5.4 mg/L at MD. Exposure to sublethal concentrations of MS-222 and eugenol altered the swimming patterns of zebrafish in a different manner depending on the time of exposure. Thus, the time required for decreasing swimming activity during exposure to anesthetics was shorter at ML than at MD, whereas the recovery period was longer during the day. In conclusion, these results revealed that the toxicity and effectiveness of both anesthetic substances is highest during daytime, the active phase of fish, thus suggesting a link between the daily rhythms of behavior and toxicity.en_UK
dc.language.isoenen_UK
dc.publisherInforma Healthcareen_UK
dc.relationSanchez-Vazquez FJ, Terry MI, Felizardo VO & Vera L (2011) Daily rhythms of toxicity and effectiveness of anesthetics (MS222 and eugenol) in zebrafish (Danio rerio). Chronobiology International, 28 (2), pp. 109-117. https://doi.org/10.3109/07420528.2010.538105en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectAnestheticsen_UK
dc.subjectchronotoxicityen_UK
dc.subjecteugenolen_UK
dc.subjectdaily rhythmsen_UK
dc.subjectMS-222en_UK
dc.subjectswimming activityen_UK
dc.subjectzebrafishen_UK
dc.titleDaily rhythms of toxicity and effectiveness of anesthetics (MS222 and eugenol) in zebrafish (Danio rerio)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Daily_rhythms_anesthetics_toxicity_zebrafish_ChronobioInt.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.3109/07420528.2010.538105en_UK
dc.citation.jtitleChronobiology Internationalen_UK
dc.citation.issn1525-6073en_UK
dc.citation.issn0742-0528en_UK
dc.citation.volume28en_UK
dc.citation.issue2en_UK
dc.citation.spage109en_UK
dc.citation.epage117en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailluisa.veraandujar@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000286901900003en_UK
dc.identifier.scopusid2-s2.0-78651435261en_UK
dc.identifier.wtid648725en_UK
dc.contributor.orcid0000-0003-0999-055Xen_UK
dcterms.dateAccepted2011-03-31en_UK
dc.date.filedepositdate2014-03-28en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorSanchez-Vazquez, F Javier|en_UK
local.rioxx.authorTerry, Marta I|en_UK
local.rioxx.authorFelizardo, Viviane O|en_UK
local.rioxx.authorVera, LM|0000-0003-0999-055Xen_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameDaily_rhythms_anesthetics_toxicity_zebrafish_ChronobioInt.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0742-0528en_UK
Appears in Collections:Aquaculture Journal Articles

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