Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19601
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dc.contributor.authorMcStay, Elsbethen_UK
dc.contributor.authorMigaud, Herveen_UK
dc.contributor.authorVera, LMen_UK
dc.contributor.authorSanchez-Vazquez, F Javieren_UK
dc.contributor.authorDavie, Andrewen_UK
dc.date.accessioned2018-01-27T04:20:35Z-
dc.date.available2018-01-27T04:20:35Z-
dc.date.issued2014-03en_UK
dc.identifier.urihttp://hdl.handle.net/1893/19601-
dc.description.abstractThe photoreceptive teleost pineal is considered to be essential to the generation, synchronisation and maintenance of biological rhythms, primarily via melatonin release. The role of internal (circadian clock) and external (light) signals controlling melatonin production in the fish pineal differs between species, yet the reasons underpinning this remain largely unknown. Whilst in salmonids, pineal melatonin is apparently regulated directly by light, in all other studied teleosts, rhythmic melatonin production persists endogenously under the regulation of clock gene expression. To better understand the role of clocks in teleost pineals, this study aimed to characterise the expression of selected clock genes in vitro under different photoperiodic conditions in comparison to in vivo in both Atlantic salmon (Salmo salar) and in European seabass (Dicentrarchus labrax) (in vitro 12L:12D), a species known to display endogenous rhythmic melatonin synthesis. Results revealed no rhythmic clock gene (Clock, Period 1 &2) expression in Atlantic salmon or European seabass (Clock and Period 1) pineal in vitro. However rhythmic expression of Cryptochrome 2 and Period 1 in the Atlantic salmon pineal was observed in vivo, which infers extra-pineal regulation of clocks in this species. No rhythmic arylalkylamine N-acetyltransferase 2 (Aanat2) expression was observed in the Atlantic salmon yet in the European seabass, circadian Aanat2 expression was observed. Subsequent in silico analysis of available Aanat2 genomic sequences reveals that Atlantic salmon Aanat2 promoter sequences do not contain similar regulatory architecture as present in European seabass, and previously described in other teleosts which alludes to a loss in functional connection in the pathway.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationMcStay E, Migaud H, Vera L, Sanchez-Vazquez FJ & Davie A (2014) Comparative study of pineal clock gene and AANAT2 expression in relation to melatonin synthesis in Atlantic salmon (Salmo salar) and European seabass (Dicentrarchus labrax). Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 169, pp. 77-89. https://doi.org/10.1016/j.cbpa.2013.12.011en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectPineal glanden_UK
dc.subjectClock genesen_UK
dc.subjectMelatoninen_UK
dc.subjectAanat2en_UK
dc.subjectAtlantic salmonen_UK
dc.subjectEuropean seabassen_UK
dc.titleComparative study of pineal clock gene and AANAT2 expression in relation to melatonin synthesis in Atlantic salmon (Salmo salar) and European seabass (Dicentrarchus labrax)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[CompBiochemandPhysA 2014.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.cbpa.2013.12.011en_UK
dc.identifier.pmid24361868en_UK
dc.citation.jtitleComparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiologyen_UK
dc.citation.issn1095-6433en_UK
dc.citation.volume169en_UK
dc.citation.spage77en_UK
dc.citation.epage89en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailluisa.veraandujar@stir.ac.uken_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Murciaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000331428700011en_UK
dc.identifier.scopusid2-s2.0-84892552338en_UK
dc.identifier.wtid648789en_UK
dc.contributor.orcid0000-0002-5404-7512en_UK
dc.contributor.orcid0000-0003-0999-055Xen_UK
dc.contributor.orcid0000-0002-9524-618Xen_UK
dc.date.accepted2013-12-13en_UK
dcterms.dateAccepted2013-12-13en_UK
dc.date.filedepositdate2014-03-25en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMcStay, Elsbeth|en_UK
local.rioxx.authorMigaud, Herve|0000-0002-5404-7512en_UK
local.rioxx.authorVera, LM|0000-0003-0999-055Xen_UK
local.rioxx.authorSanchez-Vazquez, F Javier|en_UK
local.rioxx.authorDavie, Andrew|0000-0002-9524-618Xen_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameCompBiochemandPhysA 2014.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1095-6433en_UK
Appears in Collections:Aquaculture Journal Articles

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