Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/19300
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise
Authors: Brown, Frankie F
Bigley, Austin B
Sherry, Chris
Neal, Craig M
Witard, Oliver
Simpson, Richard
Galloway, S D
Contact Email: oliver.witard@stir.ac.uk
Keywords: Immunosurveillance
CD4+ T-lymphocytes
CD8+ T-lymphocytes
Trained
Untrained
Issue Date: Jul-2014
Publisher: Elsevier
Citation: Brown FF, Bigley AB, Sherry C, Neal CM, Witard O, Simpson R & Galloway SD (2014) Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise, Brain, Behavior, and Immunity, 39, pp. 152-159.
Abstract: Purpose: Investigate training status and sex effects on the redistribution of senescent and naïve T-lymphocytes following acute exercise. Methods: Sixteen (8 male, 8 female) trained (18.3 ± 1.7 yr) soccer players (Tr) and sixteen (8 male, 8 female) untrained (19.3 ± 2.0 yr) controls (UTr) performed a treadmill running test to volitional exhaustion. Blood lymphocytes were isolated before (Pre), immediately post, and 1-h post-exercise for assessment of cell surface expression of CD28 and CD57 on CD4+ and CD8+ T-lymphocyte subsets. Plasma was used to determine cytomegalovirus (CMV) serostatus. Results: Exercise elicited a redistribution of T-lymphocyte subsets. Senescent CD4+ and CD8+ T-lymphocytes increased by 42.4% and 45.9% respectively, while naïve CD4+ and CD8+ T-lymphocytes decreased by 8.7% and 22.5% respectively in response to exercise. A main effect (P < 0.05) of training status was observed for senescent CD4+, CD8+ and naïve CD8+ T-lymphocytes: UTr had a higher proportion of senescent and a lower proportion of naïve CD8+ T-lymphocytes than Tr. A main effect (P < 0.05) of sex was observed in senescent CD4+, CD8+ and naïve CD4+, CD8+ T-lymphocytes. Males had a higher proportion of senescent and lower proportion of naïve T-lymphocytes than females. A sex-by-training status interaction (P < 0.05) was observed for the senescent and naïve CD4+ T-lymphocytes (but not CD8+) with the highest percentage of senescent and lowest percentage of naïve T-lymphocytes observed in UTr males. CMV exerted a significant main covariate effect (P < 0.05) in the senescent and naïve (P < 0.05) CD8+ T-lymphocytes but not in the senescent and naïve CD4+ T-lymphocytes. Conclusion: This study highlights important sex and training status differences in the senescent and naïve T-lymphocyte redistribution in response to exercise that warrants further investigation.
Type: Journal Article
URI: http://hdl.handle.net/1893/19300
DOI Link: http://dx.doi.org/10.1016/j.bbi.2013.10.031
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Stirling
University of Stirling
University of Stirling
University of Stirling
Sport
University of Stirling
Sport

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