Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/18351
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Colorectal complications of end-stage renal failure and renal transplantation: a review
Authors: Parnaby, Craig N
Barrow, Elizabeth J
Edirimanne, Senarath B
Parrott, Neil R
Frizelle, Frank A
Watson, Angus
Contact Email: angus.watson@stir.ac.uk
Keywords: End-stage renal failure
renal transplantation
diverticular disease
colitis
colorectal cancer
anal cancer
Issue Date: Apr-2012
Publisher: Wiley-Blackwell for The Association of Coloproctology of Great Britain and Ireland
Citation: Parnaby CN, Barrow EJ, Edirimanne SB, Parrott NR, Frizelle FA & Watson A (2012) Colorectal complications of end-stage renal failure and renal transplantation: a review, Colorectal Disease, 14 (4), pp. 403-415.
Abstract: Aim: End-stage renal failure (ESRF) and renal transplant recipients are thought to be associated with an increased risk of colorectal complications. Method: A review of the literature was performed to assess the prevalence and outcome in both benign and malignant colorectal disease. Results: No prospective randomized studies assessing colorectal complications in ESRF or renal transplant were identified. Case series and case reports have described the incidence and management of benign colorectal complications. Complications included diverticulitis, infective colitis, colonic bleeding and colonic perforation. There was insufficient evidence to associate diverticular disease with adult polycystic kidney disease. Three population-based studies have shown up to a twofold increased incidence of colonic cancer but not rectal cancer for renal transplant recipients. Bowel cancer screening (as per the general population) by faecal occult blood testing appears justified for renal transplant patients; however, evidence suggests that consideration of starting screening at a younger age may be worthwhile because of an increased risk of developing colonic cancer. Two population-based studies have shown a threefold and 10-fold increased incidence of anal cancer for renal transplant recipients. A single case-control study demonstrated significant increased prevalence of anal human papillomavirus (HPV) and intraepithelial neoplasia (AIN) in patients with established renal transplants. Conclusions: Despite the lack of high-level evidence, ESRF and renal transplantation were associated with colorectal complications that could result in major morbidity and mortality. Bowel cancer screening in this patient group appears justified. The effectiveness of screening for HPV, AIN and anal cancer in renal transplant recipients remains unclear.
Type: Journal Article
URI: http://hdl.handle.net/1893/18351
DOI Link: http://dx.doi.org/10.1111/j.1463-1318.2010.02491.x
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Raigmore Hospital
Central Manchester University Hospitals NHS Trust
Christchurch Hospital, New Zealand
Central Manchester University Hospitals NHS Trust
Christchurch Hospital, New Zealand
HS Research - Highland

Files in This Item:
File Description SizeFormat 
Watson_Colorectal Disease_2012.pdf103.64 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.