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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe
Authors: Weidmann, Manfred
Ruzek, Daniel
Krivanec, Karel
Zoller, Gudrun
Essbauer, Sandra
Pfeffer, Martin
Zanotto, Paolo M D A
Hufert, Frank T
Dobler, Gerhard
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Issue Date: Aug-2011
Publisher: Society for General Microbiology
Citation: Weidmann M, Ruzek D, Krivanec K, Zoller G, Essbauer S, Pfeffer M, Zanotto PMAD, Hufert FT & Dobler G (2011) Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe, Journal of General Virology, 92 (8), pp. 1906-1916.
Abstract: Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic, and four isolates and nine TBEV strains detected in ticks from Germany, covering more than half a century from 1954 to 2009, were sequenced and subjected to phylogenetic and Bayesian phylodynamic analysis to determine the phylogeography of TBEV in central Europe. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the Czech Republic that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8×10-4 substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Žďár Kaplice proved for the first time that TBEV is indeed subject to local evolution.
Type: Journal Article
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Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
Czech Academy of Sciences
Ministry of Defence & Armed Forces of the Czech Republic
Bunderwehr Institute for Microbiology
Bunderwehr Institute for Microbiology
University Leipzig
University of Sao Paulo
University of Gottingen, Georg-August University
Bunderwehr Institute for Microbiology

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