Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/18255
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Genetic characterization of Erve virus, a European Nairovirus distantly related to Crimean-Congo hemorrhagic fever virus
Authors: Dilcher, Meik
Koch, Andrea
Hasib, Lekbira
Dobler, Gerhard
Hufert, Frank T
Weidmann, Manfred
Contact Email: m.w.weidmann@stir.ac.uk
Keywords: Erve virus
Bunyavirus
Nairovirus
Thiafora group
Issue Date: Dec-2012
Publisher: Springer
Citation: Dilcher M, Koch A, Hasib L, Dobler G, Hufert FT & Weidmann M (2012) Genetic characterization of Erve virus, a European Nairovirus distantly related to Crimean-Congo hemorrhagic fever virus, Virus Genes, 45 (3), pp. 426-432.
Abstract: Erve virus (ERVEV) is a European Nairovirus that is suspected to cause severe headache (thunderclap headache) and intracerebral hemorrhage. The mode of transmission to humans (ticks or mosquitoes) is still unknown. Currently, no standardized testing method for ERVEV exists and only a small partial sequence of the polymerase gene is available. Here, we present the first complete genome sequence of ERVEV S, M, and L segments. Phylogenetic comparison of the amino acid sequence of the L-protein (RNA-dependent RNA polymerase) revealed only 48 % homology to available L-protein sequences of other Nairoviruses like Crimean-Congo hemorrhagic fever virus, Nairobi sheep disease virus, Hazara virus, Kupe virus, and Dugbe virus. Among themselves, these Nairoviruses show 62-89 % homology in the L-protein sequences. Therefore, ERVEV seems to be only distantly related to other Nairoviruses. The new sequence data can be used for the development of diagnostic methods and the identification of the natural vector.
Type: Journal Article
URI: http://hdl.handle.net/1893/18255
DOI Link: http://dx.doi.org/10.1007/s11262-012-0796-8
Rights: Copyright is held by The Author(s) 2012. This article is published with open access at Springerlink.com
Affiliation: University of Gottingen, Georg-August University
University of Gottingen, Georg-August University
University of Gottingen, Georg-August University
Bunderwehr Institute for Microbiology
University of Gottingen, Georg-August University
Aquaculture

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