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Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Human Streptococcus agalactiae strains in aquatic mammals and fish
Authors: Delannoy, Christian M J
Crumlish, Margaret
Fontaine, Michael C
Pollock, Jolinda
Foster, Geoff
Dagleish, Mark P
Turnbull, James
Zadoks, Ruth N
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Keywords: Streptococcus agalactiae
Sea mammal
Aquatic epidemiology
Molecular epidemiology
Issue Date: Feb-2013
Publisher: BioMed Central Ltd
Citation: Delannoy CMJ, Crumlish M, Fontaine MC, Pollock J, Foster G, Dagleish MP, Turnbull J & Zadoks RN (2013) Human Streptococcus agalactiae strains in aquatic mammals and fish, BMC Microbiology, 13 (1), Art. No.: 41.
Abstract: Background: In humans, Streptococcus agalactiae or group B streptococcus (GBS) is a frequent coloniser of the rectovaginal tract, a major cause of neonatal infectious disease and an emerging cause of disease in non-pregnant adults. In addition, Streptococcus agalactiae causes invasive disease in fish, compromising food security and posing a zoonotic hazard. We studied the molecular epidemiology of S. agalactiae in fish and other aquatic species to assess potential for pathogen transmission between aquatic species and humans. Methods: Isolates from fish (n = 26), seals (n = 6), a dolphin and a frog were characterized by pulsed-field gel electrophoresis, multilocus sequence typing and standardized 3-set genotyping, i.e. molecular serotyping and profiling of surface protein genes and mobile genetic elements. Results: Four subpopulations of S. agalactiae were identified among aquatic isolates. Sequence type (ST) 283 serotype III-4 and its novel single locus variant ST491 were detected in fish from Southeast Asia and shared a 3-set genotype identical to that of an emerging ST283 clone associated with invasive disease of adult humans in Asia. The human pathogenic strain ST7 serotype Ia was also detected in fish from Asia. ST23 serotype Ia, a subpopulation that is normally associated with human carriage, was found in all grey seals, suggesting that human effluent may contribute to microbial pollution of surface water and exposure of sea mammals to human pathogens. The final subpopulation consisted of non-haemolytic ST260 and ST261 serotype Ib isolates, which belong to a fish-associated clonal complex that has never been reported from humans. Conclusions: The apparent association of the four subpopulations of S. agalactiae with specific groups of host species suggests that some strains of aquatic S. agalactiae may present a zoonotic or anthroponotic hazard. Furthermore, it provides a rational framework for exploration of pathogenesis and host-associated genome content of S. agalactiae strains.
Type: Journal Article
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Rights: © 2013 Delannoy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Affiliation: University of Stirling
Complex Systems
The Moredun Research Institute
The Moredun Research Institute
The Scottish Agricultural College
The Moredun Research Institute
The Moredun Research Institute

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