|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Reviewing long-term antidepressants can reduce drug burden: a prospective observational cohort study|
|Authors:||Johnson, Chris F|
Macdonald, Hector J
Buchanan, Alasdair I
|Citation:||Johnson CF, Macdonald HJ, Atkinson P, Buchanan AI, Downes N & Dougall N (2012) Reviewing long-term antidepressants can reduce drug burden: a prospective observational cohort study, British Journal of General Practice, 62 (604), pp. 584-585.|
|Abstract:||Background: Antidepressant prescribing continues to rise. Contributing factors are increased long-term prescribing and possibly the use of higher selective serotonin re-uptake inhibitor (SSRI) doses. Aim: To review general practice patients prescribed the same antidepressant long-term (≥2 years) and evaluate prescribing and management pre and post-review. Design and setting: Prospective observational cohort study using routine data from 78 urban general practices, Scotland. Method: All patients prescribed antidepressants (excluding amitriptyline) for ≥2 years were identified from records November 2009 to March 2010. GPs selected patients for face-to-face review of clinical condition and medication, December 2009 to September 2010. Pre- and post-review data were collected; average antidepressant doses and changes in prescribed daily doses were calculated. Onward referral to support services was recorded. Results: 8.6% (33 312/388 656) of all registered patients were prescribed an antidepressant, 47.1% (15 689) were defined as long-term users and 2849 (18.2%) were reviewed. 811 (28.5%) patients reviewed had a change in antidepressant therapy: 7.0% stopped, 12.8% reduced dose, 5.3% increased dose, and 3.4% changed antidepressant, resulting in 9.5% (95% CI = 9.1% to 9.8% P less than 0.001) reduction in prescribed daily dose and 8.1% reduction in prescribing costs. 6.3% were referred onwards, half to NHS Mental Health Services. Pre-review SSRI doses were 10-30% higher than previously reported. Conclusion: Almost half of all people prescribed antidepressants were long-term users. Appropriate reductions in prescribing can be achieved by reviewing patients. Higher SSRI doses may be contributing to current antidepressant growth.|
|Rights:||The publisher has granted permission for use of this work in this Repository. Published in British Journal of General Practice by Royal College of General Practitioners. Please cite as: Chris F Johnson, Hector J Macdonald, Pauline Atkinson. Reviewing long-term antidepressants can reduce drug burden: a prospective observational cohort study. Br J Gen Pract 2012; Nov;62(604): 584-5. Article can be accessed online at: http://bjgp.org/content/62/604/e773.full|
|Johnson et al BJGP 2012.pdf||197.39 kB||Adobe PDF||View/Open|
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