|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||A pilot study to explore whether airborne endotoxins play a role in the association between environmental tobacco smoke and non-respiratory, smoking-related diseases (Letter)|
|Publisher:||Oxford University Press|
|Citation:||Pell J, Tavernier G & Haw S (2011) A pilot study to explore whether airborne endotoxins play a role in the association between environmental tobacco smoke and non-respiratory, smoking-related diseases (Letter), International Journal of Epidemiology, 40 (4), pp. 1128-1129.|
|Abstract:||First paragraph: Lipopolysaccharides (endotoxins produced by Gramnegative bacteria) are present on the surface of cigarettes and have been implicated in a number of diseases. Active smoking predisposes to periodontal disease which, in turn, facilitates gastrointestinal absorption of endotoxins. Serum endotoxin concentrations are higher among active smokers and are associated with risk of cardiovascular disease. In addition to being present on the surface of cigarettes, endotoxins are present in both mainstream and sidestream cigarette smoke. Inhaled airborne endotoxins have been implicated in the pathogenesis of respiratory disease. In a guinea pig model, endotoxins have been shown to penetrate the lung barrier and be detectable in the blood. Similarly, non-smokers with occupational exposure to organic dust containing high levels of endotoxin have been shown to have increased plasma concentrations of lipopolysaccharide. However, no previous study has examined whether exposure to environmental tobacco smoke is associated with increased serum endotoxin concentrations.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Affiliation:||University of Glasgow|
HS Research - Stirling
|Haw_A_pilot_study_to_explore_whether_airborne_endotoxins_play_a_role.pdf||34.67 kB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.