Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/16653
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: A pilot study to explore whether airborne endotoxins play a role in the association between environmental tobacco smoke and non-respiratory, smoking-related diseases (Letter)
Authors: Pell, Jill
Tavernier, Gael
Haw, Sally
Contact Email: s.j.haw@stir.ac.uk
Issue Date: Aug-2011
Publisher: Oxford University Press
Citation: Pell J, Tavernier G & Haw S (2011) A pilot study to explore whether airborne endotoxins play a role in the association between environmental tobacco smoke and non-respiratory, smoking-related diseases (Letter), International Journal of Epidemiology, 40 (4), pp. 1128-1129.
Abstract: First paragraph: Lipopolysaccharides (endotoxins produced by Gramnegative bacteria) are present on the surface of cigarettes and have been implicated in a number of diseases. Active smoking predisposes to periodontal disease which, in turn, facilitates gastrointestinal absorption of endotoxins. Serum endotoxin concentrations are higher among active smokers and are associated with risk of cardiovascular disease. In addition to being present on the surface of cigarettes, endotoxins are present in both mainstream and sidestream cigarette smoke. Inhaled airborne endotoxins have been implicated in the pathogenesis of respiratory disease. In a guinea pig model, endotoxins have been shown to penetrate the lung barrier and be detectable in the blood. Similarly, non-smokers with occupational exposure to organic dust containing high levels of endotoxin have been shown to have increased plasma concentrations of lipopolysaccharide. However, no previous study has examined whether exposure to environmental tobacco smoke is associated with increased serum endotoxin concentrations.
Type: Journal Article
URI: http://hdl.handle.net/1893/16653
DOI Link: http://dx.doi.org/10.1093/ije/dyq236
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Glasgow
Wythenshawe Hospital
HS Research - Stirling

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