Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Evolutionary History of the ADRB2 Gene in Humans (Letter)
Authors: Wilson, Richard H
Moran, Colin Neil
Cole, John J
Pitsiladis, Yannis P
Bailey, Mark E S
Contact Email:
Issue Date: 12-Mar-2010
Publisher: Elsevier for The American Society of Human Genetics
Citation: Wilson RH, Moran CN, Cole JJ, Pitsiladis YP & Bailey MES (2010) Evolutionary History of the ADRB2 Gene in Humans (Letter), American Journal of Human Genetics, 86 (3), pp. 490-493.
Abstract: First paragraph: To the Editor: Recently, Cagliani et al.1 reported on the evolutionary history of the human β2-adrenoreceptor gene (ADRB2 [MIM 109690]). The authors presented their analysis of the genealogy of inferred ADRB2 haplotypes reconstructed through the use of a median-joining network approach. ADRB2 shows a high level of polymorphism, including three coding variants with altered functional properties (at codons 16, 27, and 164, hereafter referred to as C16, C27, and C164), and several suspected regulatory variants. The network presented by Cagliani et al.1 was prepared with software implementing a model that assumes no recombination but allows for recurrent mutation. We notice that most SNPs in their network are represented by recurrent mutations in nonreticulated parts of the network, which we find biologically implausible and difficult to interpret in an evolutionary context. We have prepared a network diagram for the evolution of common ADRB2 haplotypes that can be accounted for by divergence via the accumulation of mutations and rare recombination events between diverged haplotypes (Figure 1). This revised network requires no recurrent mutations (homoplasy) and accounts for the major haplotype groups of Cagliani et al., Hawkins et al., and Drysdale et al., as well as those revealed by the HapMap data, with only one recombination event.
Type: Journal Article
DOI Link:
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Glasgow
University of Glasgow
University of Glasgow
University of Glasgow

Files in This Item:
File Description SizeFormat 
Wilson AJHG 10 Evolutionary History of the ADRB2 Gene in Humans.pdf194.71 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.