Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12962
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Interaction effects between total energy and macronutrient intakes and angiotensin-converting enzyme 1 (ACE) I/D polymorphism on adiposity-related phenotypes in toddlers and preschoolers: the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS)
Authors: Kourlaba, Georgia
Pitsiladis, Yannis P
Lagou, Vasiliki
Grammatikaki, Evangelia
Moran, Colin Neil
Kondaki, Katerina
Roma-Giannikou, Eleytheria
Manios, Yannis
Contact Email: colin.moran@stir.ac.uk
Keywords: Gene-nutrient interaction
Protein intake
Carbohydrate intake
Fat intake
Issue Date: Dec-2008
Publisher: Cambridge University Press
Citation: Kourlaba G, Pitsiladis YP, Lagou V, Grammatikaki E, Moran CN, Kondaki K, Roma-Giannikou E & Manios Y (2008) Interaction effects between total energy and macronutrient intakes and angiotensin-converting enzyme 1 (ACE) I/D polymorphism on adiposity-related phenotypes in toddlers and preschoolers: the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS), British Journal of Nutrition, 100 (6), pp. 1333-1340.
Abstract: The aim of the present study was to investigate the interaction between the angiotensin-converting enzyme 1 (ACE) I/D polymorphism and energy and macronutrient intakes on adiposity-related phenotypes among toddlers and preschoolers. A representative sample of 2374 Greek children aged 1 to 5 years old was examined (Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS)). Dietary and anthropometric (i.e. BMI, waist circumference (WC)) assessments were carried out using standard procedures. DNA samples were obtained from 2102 children and were genotyped for the ACE I/D polymorphism. Among the entire population, 17 % were ‘at risk of overweight’ and a similar percentage were ‘overweight’. The frequencies of the II, ID and DD genotypes were 16, 46 and 38 %, respectively. Significant interactions were found between the ACE I/D polymorphism and total energy intake on WC (P = 0·004 for interaction) and the ACE I/D polymorphism and protein intake on BMI and being overweight (P less than 0·05 for interaction). Furthermore, it was found that the ACE I/D polymorphism may modify the effect of fat intake on WC and BMI, but this interaction disappeared after adjustment for additional potential confounders. Stratified analyses revealed that total energy is correlated with WC and protein intake is associated with BMI and being overweight only among carriers of the D-allele (i.e. DD or ID genotypes). These results suggest that the ACE I/D polymorphism may act as a modifying factor in the response of adiposity-related phenotypes to diet.
Type: Journal Article
URI: http://hdl.handle.net/1893/12962
DOI Link: http://dx.doi.org/10.1017/S0007114508988759
Rights: Publisher policy allows this work to be made available in this repository. Published in British Journal of Nutrition / Volume 100 / Issue 06 / December 2008, pp 1333-1340 Copyright © The Authors 2008 DOI: http://dx.doi.org/10.1017/S0007114508988759
Affiliation: Harokopio University
University of Glasgow
University of Glasgow
Harokopio University
Sport
Harokopio University
University of Athens
Harokopio University

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