Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12951
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Functional neurogenetics of the courtship song of male Drosophila melanogaster
Authors: Moran, Colin Neil
Kyriacou, Charalambos P
Contact Email: colin.moran@stir.ac.uk
Keywords: Drosophila
Lovesong
Neuron
Enhancer trap
Genetic feminisation
Neuronal disruption
Issue Date: Jan-2009
Publisher: Elsevier
Citation: Moran CN & Kyriacou CP (2009) Functional neurogenetics of the courtship song of male Drosophila melanogaster, Cortex, 45 (1), pp. 18-34.
Abstract: The genetically programmed courtship song of male Drosophila melanogaster has a rhythmic repetitive structure of sound pulses that is a critical component of mate recognition. This study investigates the neuronal basis of courtship song production by using the GAL4 enhancer trap paradigm to drive the expression of UASG-tetanus toxin (TNT) and UASG-transformer (tra) in subsets of cells. Of the 727 enhancer trap lines screened for courtship song defects in this way, 38 produced a phenotype, and these were used to drive the expression of Green Fluorescent Protein (GFP), thereby implicating the corresponding neuronal structures. Twelve of 13 lines which gave vigorous courtship but did not produce song, showed GFP expression in the mushroom bodies (MBs) and the giant descending neuronal tract and/or the larval interhemispheric junction (IJ). Furthermore, the relevant DNA in which the enhancer trap was inserted was isolated and sequenced in 27 of the lines, and a number of candidate genes that have been implicated in Ras and hedgehog signalling were identified. Other candidate genes that could plausibly affect courtship song were involved in mesothoracic or axonal development.
Type: Journal Article
URI: http://hdl.handle.net/1893/12951
DOI Link: http://dx.doi.org/10.1016/j.cortex.2008.05.010
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Sport
University of Leicester

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