|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Functional neurogenetics of the courtship song of male Drosophila melanogaster|
|Authors:||Moran, Colin Neil|
Kyriacou, Charalambos P
|Citation:||Moran CN & Kyriacou CP (2009) Functional neurogenetics of the courtship song of male Drosophila melanogaster, Cortex, 45 (1), pp. 18-34.|
|Abstract:||The genetically programmed courtship song of male Drosophila melanogaster has a rhythmic repetitive structure of sound pulses that is a critical component of mate recognition. This study investigates the neuronal basis of courtship song production by using the GAL4 enhancer trap paradigm to drive the expression of UASG-tetanus toxin (TNT) and UASG-transformer (tra) in subsets of cells. Of the 727 enhancer trap lines screened for courtship song defects in this way, 38 produced a phenotype, and these were used to drive the expression of Green Fluorescent Protein (GFP), thereby implicating the corresponding neuronal structures. Twelve of 13 lines which gave vigorous courtship but did not produce song, showed GFP expression in the mushroom bodies (MBs) and the giant descending neuronal tract and/or the larval interhemispheric junction (IJ). Furthermore, the relevant DNA in which the enhancer trap was inserted was isolated and sequenced in 27 of the lines, and a number of candidate genes that have been implicated in Ras and hedgehog signalling were identified. Other candidate genes that could plausibly affect courtship song were involved in mesothoracic or axonal development.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
University of Leicester
|Moran CORTEX 09 Functional neurogenomics of the courtship song of male Drosophila melanogaster.pdf||1.47 MB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.