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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Mitochondrial DNA lineages of elite Ethiopian athletes
Authors: Scott, Robert A
Wilson, Richard H
Goodwin, William H
Moran, Colin Neil
Georgiades, Evelina
Wolde, Bezabhe
Pitsiladis, Yannis P
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Keywords: Ethiopia
mitochondrial DNA
East Africa
Issue Date: Mar-2005
Publisher: Elsevier
Citation: Scott RA, Wilson RH, Goodwin WH, Moran CN, Georgiades E, Wolde B & Pitsiladis YP (2005) Mitochondrial DNA lineages of elite Ethiopian athletes, Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 140 (3), pp. 497-503.
Abstract: Previous studies have hypothesised that mitochondrial DNA (mtDNA) polymorphisms may influence aerobic performance. The matrilineal inheritance and accumulation of polymorphisms in mtDNA means that mtDNA haplogroups, characterised by key polymorphisms, are often represented at different frequencies in different populations. The present study aimed to compare the mtDNA haplogroup distribution of elite Ethiopian athletes relative to the general Ethiopian population. The haplogroup distribution of 76 endurance athletes (E), members of the Ethiopian national athletics team, was compared to 108 members of the general Ethiopian population (C). DNA was extracted from buccal swabs and haplogroups assigned by sequencing part of the hypervariable sequence (HVS-I), followed by analysis of key coding-region polymorphisms. A high proportion of African ‘L’ haplogroups was found in athletes and controls (C=53%; E=55%). Haplogroup distribution of endurance runners did not differ from that of C (P=0.63). Elite Ethiopian athletes are not a mitochondrially distinct group relative to the Ethiopian population. It appears that environment and, perhaps, polymorphisms in the nuclear genome are more important determinants of Ethiopian running success than mtDNA polymorphisms.
Type: Journal Article
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Affiliation: University of Glasgow
University of Glasgow
University of Central Lancashire
University of Glasgow
Kotebe College of Teacher Education
University of Glasgow

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