Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12946
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males
Authors: Scott, Robert A
Bailey, Mark E S
Moran, Colin Neil
Wilson, Richard H
Fuku, Noriyuki
Tanaka, Masashi
Tsiokanos, Athanasios
Jamurtas, Athanasios Z
Grammatikaki, Evangelia
Moschonis, George
Manios, Yannis
Pitsiladis, Yannis P
Contact Email: colin.moran@stir.ac.uk
Keywords: obesity
FTO
physical activity
Issue Date: Dec-2010
Publisher: European Society of Human Genetics
Citation: Scott RA, Bailey MES, Moran CN, Wilson RH, Fuku N, Tanaka M, Tsiokanos A, Jamurtas AZ, Grammatikaki E, Moschonis G, Manios Y & Pitsiladis YP (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males, European Journal of Human Genetics, 18 (12), pp. 1339-1343.
Abstract: Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk. Studies of the interaction between genetic and environmental factors such as physical activity (PA) will promote the understanding of how lifestyle can modulate genetic contributions to obesity. In this study, we investigated the effect of FTO genotype, and interactions with PA or energy intake, in young children and adolescents. In all, 1–5-year-old children from the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS) study (N=1980) and 11–18-year-old Greek adolescents (N=949) were measured for adiposity-related phenotypes and genotyped at the FTO single-nucleotide polymorphism (SNP) marker, rs17817449. Adolescents were classified as physically active or inactive based on self-reported levels of PA. In adolescents, FTO genotype influenced weight (P=0.001) and BMI (P=0.007). There was also a significant SNP*PA*gender interaction (P=0.028) on BMI, which reflected the association between FTO genotype and BMI in males (P=0.016), but not females (P=0.15), and significant SNP*PA interaction in males (P=0.007), but not females (P=0.74). The FTO genotype effect was more pronounced in inactive than active males. Inactive males homozygous for the G allele had a mean BMI 3 kg/m2 higher than T carriers (P=0.008). In the GENESIS study, no significant association between FTO genotype and adiposity was found. The present findings highlight PA as an important factor modifying the effect of FTO genotype.
Type: Journal Article
URI: http://hdl.handle.net/1893/12946
DOI Link: http://dx.doi.org/10.1038/ejhg.2010.131
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Glasgow
University of Glasgow
Sport
University of Glasgow
Tokyo Metropolitan Institute of Gerontology
Tokyo Metropolitan Institute of Gerontology
University of Thessaly
University of Thessaly
Harokopio University
Harokopio University
Harokopio University
University of Glasgow

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