Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12945
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism
Authors: Lagou, Vasiliki
Manios, Yannis
Moran, Colin Neil
Bailey, Mark E S
Grammatikaki, Evangelia
Oikonomou, Evdokia
Ioannou, Elina
Moschonis, George
Wilson, Richard H
Pitsiladis, Yannis P
Contact Email: colin.moran@stir.ac.uk
Keywords: ACE I/D polymorphism
association study
adiposity
related phenotypes
toddlers and preschoolers
Issue Date: Jul-2007
Publisher: Nature Publishing Group
Citation: Lagou V, Manios Y, Moran CN, Bailey MES, Grammatikaki E, Oikonomou E, Ioannou E, Moschonis G, Wilson RH & Pitsiladis YP (2007) Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism, International Journal of Obesity, 31 (7), pp. 1052-1060.
Abstract: Objectives: To investigate the relationship between the angiotensin I-converting enzyme 1 (ACE) I/D polymorphism and adiposity-related phenotypes in a large cohort of toddlers and preschoolers. Methods: Body composition measurements and DNA samples were obtained from 2102 Greek children aged 1–6 years, as part of a large-scale epidemiological study (GENESIS). All children were genotyped for the ACE I/D polymorphism and gender- and age-stratified statistical analyses were performed. Results: In girls aged 4–6 years, the D-allele was associated with higher measurements of body mass index (BMI) (P=0.018), waist (P=0.001) and upper arm (P=0.013) circumferences, genotype accounting for 2.5, 4 and 3% of the phenotypic variance, respectively. In boys, the D-allele showed strong associations with lower BMI (P=0.001) at the age of 1–2 years that explained 17% of the phenotypic variance and with larger suprailiac skinfold (P=0.008) at 3–4 years old that explained 2% of the variance. No other significant associations between the ACE I/D polymorphism and adiposity-related phenotypes were found. In girls, the age at which significant associations were revealed coincided with the age at which BMI was observed to increase after its developmental nadir, but this feature of the association was not observed in boys. Conclusions: The ACE I/D polymorphism is associated with developmental and physiological changes in adiposity-related traits during early childhood in a gender- and age-specific manner.
Type: Journal Article
URI: http://hdl.handle.net/1893/12945
DOI Link: http://dx.doi.org/10.1038/sj.ijo.0803605
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Glasgow
Harokopio University
Sport
University of Glasgow
Harokopio University
Harokopio University
Harokopio University
Harokopio University
University of Glasgow
University of Glasgow

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