Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The reliability of the IL-6, sIL-6R and sgp130 response to a preloaded time trial
Authors: Walshe, Ian
Robson-Ansley, Paula
Gibson, Alan St Clair
Lawrence, Claire
Thompson, Kevin G
Ansley, Les
Contact Email:
Keywords: Exercise
Time trial
Issue Date: Oct-2010
Publisher: Springer
Citation: Walshe I, Robson-Ansley P, Gibson ASC, Lawrence C, Thompson KG & Ansley L (2010) The reliability of the IL-6, sIL-6R and sgp130 response to a preloaded time trial, European Journal of Applied Physiology, 110 (3), pp. 619-625.
Abstract: Interleukin-6 (IL-6) is a cytokine that can mediate numerous biological actions including fatigue. Circulating IL-6 increases during prolonged exercise, and furthermore, the signalling receptors sIL-6R and sgp130 are also increased. The variability of the response of these markers to exercise is unknown; therefore, we examined the changes in these markers to a preloaded time trial bout of running. Nine males performed three identical trials where participants ran at 60% for 2 h interspersed with 30 s at 90% TeX every 10 min, followed by a 5-km time trial. Blood samples were drawn at baseline, following the 2-h bout, post time trial, 1 h post time trial and the following morning. Results showed that between-subject variability (CVg) was greater than within-subject variation (CVi) for the three markers. IL-6, sIL-6R and sgp130 demonstrated a CVi of 15.3-25.5%, 15.0-17.6% and 6.2-9.4% variation, respectively, across the time points. When the data from the second and third trials were analysed independently, CVi was reduced which is supported by the time trial results for which CVi improve (4.7-2.4%). In conclusion, the results indicate that a large variation in response to exercise can be reduced following a habituation trial.
Type: Journal Article
DOI Link:
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Sport
Northumbria University
Northumbria University
Northumbria University
Northumbria University

Files in This Item:
File Description SizeFormat 
the reliability of the IL-6.pdf257.35 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.