Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12473
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The response of intracellular signaling and muscle-protein metabolism to nutrition and exercise
Authors: Tipton, Kevin
Sharp, Carwyn P
Contact Email: k.d.tipton@stir.ac.uk
Keywords: Translation initiation
arteriovenous balance
amino acids
protein synthesis
Issue Date: Sep-2005
Publisher: Taylor & Francis for the European College of Sport Science
Citation: Tipton K & Sharp CP (2005) The response of intracellular signaling and muscle-protein metabolism to nutrition and exercise, European Journal of Sport Science, 5 (3), pp. 107-121.
Abstract: In recent years, a body of literature examining the response of muscle-protein metabolism to exercise and nutrition has arisen. Developments in methods, especially stable isotopic tracer methodology, have allowed much information to be gathered in vivo in humans. The metabolic mechanism behind increased muscle mass requires that muscle-protein synthesis exceeds breakdown, i.e., net muscle-protein synthesis. Increased net muscle-protein balance may occur due to exercise, but net synthesis may occur only with the addition of nutrients, particularly a source of amino acids. The major impact of increased amino acid availability on net muscle-protein balance is due to stimulation of muscle-protein synthesis and less to inhibition of muscle-protein breakdown. Amino acids seem to stimulate muscle-protein synthesis, not only by mass action, i.e., providing substrate, but also as signals for initiation of protein synthesis. Stimulation of muscle-protein synthesis by amino acid ingestion may be linked to increased intracellular amino acid levels and/or to changing amino acid levels in the blood. Carbohydrate ingestion, most likely through the action of insulin, also may play a role in the response of muscle to exercise and nutrition. There is very little research in humans in vivo on the intracellular signaling that is linked to muscle-protein synthesis. It is clear that intracellular signaling responds to both insulin and amino acids, but the interactions with exercise are not well known; however, the details of the pathways have only just begun to be investigated, especially in humans. Delineation of these pathways is complicated, and there is little doubt that multiple intracellular signaling pathways with several levels of communication are involved in the hypertrophy process in response to nutrition and exercise. A systematic investigation of the relationship of the signaling to insulin and amino acids combined with exercise will provide important information, especially for populations vulnerable to muscle loss.
Type: Journal Article
URI: http://hdl.handle.net/1893/12473
DOI Link: http://dx.doi.org/10.1080/17461390500233607
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Sport
University of Texas

Files in This Item:
File Description SizeFormat 
Tipton_2005_The_response_of_intracellular_signaling.pdf190.39 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.