Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12472
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Testosterone injection stimulates net protein synthesis but not tissue amino acid transport
Authors: Ferrando, Arny A
Tipton, Kevin
Doyle, David J
Phillips, Stuart M
Cortiella, Joaquin
Wolfe, Robert R
Contact Email: k.d.tipton@stir.ac.uk
Keywords: Amino nitrogen uptake
Fractional breakdown rate
Issue Date: Nov-1998
Publisher: American Physiological Society
Citation: Ferrando AA, Tipton K, Doyle DJ, Phillips SM, Cortiella J & Wolfe RR (1998) Testosterone injection stimulates net protein synthesis but not tissue amino acid transport, American Journal of Physiology - Endocrinology and Metabolism, 275 (5), pp. E864-E871.
Abstract: Testosterone administration (T) increases lean body mass and muscle protein synthesis. We investigated the effects of short-term T on leg muscle protein kinetics and transport of selected amino acids by use of a model based on arteriovenous sampling and muscle biopsy. Fractional synthesis (FSR) and breakdown (FBR) rates of skeletal muscle protein were also directly calculated. Seven healthy men were studied before and 5 days after intramuscular injection of 200 mg of testosterone enanthate. Protein synthesis increased twofold after injection (P less than 0.05), whereas protein breakdown was unchanged. FSR and FBR calculations were in accordance, because FSR increased twofold (P less than 0.05) without a concomitant change in FBR. Net balance between synthesis and breakdown became more positive with both methodologies (P less than 0.05) and was not different from zero. T injection increased arteriovenous essential and nonessential nitrogen balance across the leg (P less than 0.05) in the fasted state, without increasing amino acid transport. Thus T administration leads to an increased net protein synthesis and reutilization of intracellular amino acids in skeletal muscle.
Type: Journal Article
URI: http://hdl.handle.net/1893/12472
URL: http://ajpendo.physiology.org/content/275/5/E864.abstract
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Texas
Sport
University of Texas
University of Texas
University of Texas
University of Texas

Files in This Item:
File Description SizeFormat 
Tipton_2002_Testosterone_injection_stimulates_net_protein_synthesis.pdf162.76 kBAdobe PDFUnder Embargo until 31/12/2999     Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependant on the depositor still being contactable at their original email address.

This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.