Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/1245
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women
Authors: Parente, Valeria
D’Antona, Giuseppe
Adami, Raffaella
Miotti, Danilo
Capodaglio, Paolo
De, Vito Giuseppe
Bottinelli, Roberto
Contact Email: giuseppe.devito@stir.ac.uk
Keywords: Ageing
Exercise training
Skinned fibres
Myosin isoforms
Humans
Issue Date: Nov-2008
Publisher: Springer-Verlag
Citation: Parente V, D’Antona G, Adami R, Miotti D, Capodaglio P, De Vito G & Bottinelli R (2008) Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women, European Journal of Applied Physiology, 104 (5), pp. 885-893.
Abstract: Four elderly women (78 ± 4.3 years) were resistance trained (RT) for one year and needle biopsies of the vastus lateralis muscle were taken pre- and post-RT. A training intensity of 60% one-repetition maximum (1RM) was adopted for the entire duration of the study. Following RT, significant gain in isometric force of the quadriceps muscles was observed and MHC isoform distribution of vastus lateralis muscle showed a very significant shift from MHC-1 and MHC-2X towards MHC-2A, i.e. a bi-directional shift. A large population (n = 310) of individual skinned muscle fibres were dissected from biopsy samples and used for determination of cross-sectional area (CSA), specific force (Po/CSA) and unloaded shortening velocity (Vo) at 12°C and maximum activation. Fibres were classified on the basis of their MHC isoform content determined by SDS-PAGE in three pure fibre types (1, 2A and 2X) and two hybrid fibre types (1-2A and 2AX). Whereas the CSA of individual muscle fibres did not change, Po/CSA was significantly higher in both type 1 and type 2A fibres post training. Vo of type 1 fibres was significantly higher post-training, whereas no change in Vo was observed in type 2A fibres. The number of pure type 2X fibres was very low especially post-training and did not enable a statistically significant comparison. The data suggest that in elderly women moderate and prolonged RT: (1) can determine similar adaptations in MHC distribution of skeletal muscle to those expected in young subjects; (2) can improve function of muscle fibres.
Type: Journal Article
URI: http://hdl.handle.net/1893/1245
DOI Link: http://dx.doi.org/10.1007/s00421-008-0845-0
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Pavia
University of Pavia
University of Pavia
Fondazione Salvatore Maugeri (IRCCS)
Ospedale San Giuseppe, Italy
Sport
University of Pavia

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