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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12184
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dc.contributor.authorTerriere, Emmaen_UK
dc.contributor.authorSharman, Mikeen_UK
dc.contributor.authorDonaghey, Claireen_UK
dc.contributor.authorHerrmann, Lucie Len_UK
dc.contributor.authorLonie, Jane Aen_UK
dc.contributor.authorStrachan, Marionen_UK
dc.contributor.authorDougall, Nadineen_UK
dc.contributor.authorBest, Jonathan J Ken_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.contributor.authorPimlott, Sallyen_UK
dc.contributor.authorPatterson, Jamesen_UK
dc.contributor.authorWyper, David Jen_UK
dc.date.accessioned2014-09-15T19:42:57Z-
dc.date.available2014-09-15T19:42:57Zen_UK
dc.date.issued2008-04en_UK
dc.identifier.urihttp://hdl.handle.net/1893/12184-
dc.description.abstractFive patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand 123I-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen's d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer's disease.en_UK
dc.language.isoenen_UK
dc.publisherSpringeren_UK
dc.relationTerriere E, Sharman M, Donaghey C, Herrmann LL, Lonie JA, Strachan M, Dougall N, Best JJK, Ebmeier KP, Pimlott S, Patterson J & Wyper DJ (2008) Alpha4 Beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: Methods of scan analysis. Neurochemical Research, 33 (4), pp. 643-651. https://doi.org/10.1007/s11064-007-9517-4en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectAlzheimer's diseaseen_UK
dc.subjectdementiaen_UK
dc.subjectnicotinic acetylcholine receptorsen_UK
dc.subjectsingle photon emission tomographyen_UK
dc.subjectDementia therapyen_UK
dc.subjectAlzheimer Disease diagnosisen_UK
dc.subjectAlzheimer Disease therapyen_UK
dc.subjectCognition disordersen_UK
dc.titleAlpha4 Beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: Methods of scan analysisen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Alpha4beta2-nicotinic.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1007/s11064-007-9517-4en_UK
dc.citation.jtitleNeurochemical Researchen_UK
dc.citation.issn1573-6903en_UK
dc.citation.issn0364-3190en_UK
dc.citation.volume33en_UK
dc.citation.issue4en_UK
dc.citation.spage643en_UK
dc.citation.epage651en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailnadine.dougall@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationWest of Scotland Radionuclide Dispensaryen_UK
dc.contributor.affiliationSouthern General Hospitalen_UK
dc.contributor.affiliationSouthern General Hospitalen_UK
dc.identifier.isiWOS:000253698600006en_UK
dc.identifier.scopusid2-s2.0-40349093080en_UK
dc.identifier.wtid713743en_UK
dc.contributor.orcid0000-0003-3462-6960en_UK
dcterms.dateAccepted2008-04-30en_UK
dc.date.filedepositdate2013-04-22en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorTerriere, Emma|en_UK
local.rioxx.authorSharman, Mike|en_UK
local.rioxx.authorDonaghey, Claire|en_UK
local.rioxx.authorHerrmann, Lucie L|en_UK
local.rioxx.authorLonie, Jane A|en_UK
local.rioxx.authorStrachan, Marion|en_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.authorBest, Jonathan J K|en_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.authorPimlott, Sally|en_UK
local.rioxx.authorPatterson, James|en_UK
local.rioxx.authorWyper, David J|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameAlpha4beta2-nicotinic.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0364-3190en_UK
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