Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/11790
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dc.contributor.authorSchoultz, Mariyanaen_UK
dc.contributor.authorAtherton, Iainen_UK
dc.contributor.authorHubbard, Gillen_UK
dc.contributor.authorWatson, Angusen_UK
dc.date.accessioned2014-09-15T14:11:49Z-
dc.date.available2014-09-15T14:11:49Z-
dc.date.issued2013-01-23en_UK
dc.identifier.urihttp://hdl.handle.net/1893/11790-
dc.description.abstractBackground: Inflammatory bowel disease is an idiopathic chronic disease that affects around 28 million people worldwide. Symptoms are distressing and have a detrimental effect on patients' quality of life. A possible link between exacerbation of symptoms and psychological factors has been suspected but not established. Previous reviews concerned with this link had conceptual and methodological limitations. In this paper we set out a protocol that lays the foundations for a systematic review that will address these shortcomings. The aim of this review is to provide researchers and clinicians with clarity on the role of psychological factors in inflammatory bowel disease symptom exacerbation. Method/design: We will identify all original, published, peer reviewed studies relevant to the topic and published in English from inception to November 2012. The databases MEDLINE, EMBASE, CINAHL and PsychINFO will be systematically searched. The search terms will include: inflammatory bowel disease, Crohn's disease, ulcerative colitis, psychological stress, mental stress, life stress, family stress, hassles, social stress, coping, mood disorders, anxiety and depression in sequential combinations. Studies will be screened according to predetermined inclusion and exclusion criteria by two reviewers. We will include clinical prospective cohort studies of all human participants aged 18 years or over with a diagnosis of inflammatory bowel disease. All eligible papers will be independently and critically appraised using the Critical Appraisal Skills Programme (CASP) tool by two reviewers. Two reviewers will independently extract and synthesise data from the studies using a predefined data extraction sheet. Disagreements will be resolved by discussion between reviewers and a third party will be consulted if agreement is not reached. Synthesised data will be analysed using Bradford Hill criterion for causality. If data permits, meta-analysis will be performed. Discussion: This study will provide the most comprehensive review and synthesis of current evidence around the link between psychological factors and symptom exacerbation in inflammatory bowel disease. Results will inform clinicians in appropriate intervention development for this patient group that would reduce symptom exacerbation and therefore improve patients' quality of life.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Central Ltden_UK
dc.relationSchoultz M, Atherton I, Hubbard G & Watson A (2013) Assessment of causal link between psychological factors and symptom exacerbation in inflammatory bowel disease: a protocol for systematic review of prospective cohort studies. Systematic Reviews, 2 (8). https://doi.org/10.1186/2046-4053-2-8en_UK
dc.rights© 2013 Schoultz et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectInflammatory bowel diseaseen_UK
dc.subjectCrohn’s diseaseen_UK
dc.subjectUlcerative colitisen_UK
dc.subjectPsychological factorsen_UK
dc.subjectSymptom exacerbationen_UK
dc.subjectSystematic review protocolen_UK
dc.titleAssessment of causal link between psychological factors and symptom exacerbation in inflammatory bowel disease: a protocol for systematic review of prospective cohort studiesen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/2046-4053-2-8en_UK
dc.identifier.pmid23343187en_UK
dc.citation.jtitleSystematic Reviewsen_UK
dc.citation.issn2046-4053en_UK
dc.citation.volume2en_UK
dc.citation.issue8en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailgill.hubbard@uhi.ac.uken_UK
dc.contributor.affiliationHS UG Regulated - Stirling - LEGACYen_UK
dc.contributor.affiliationHealth Sciences Research - Highland - LEGACYen_UK
dc.contributor.affiliationCancer Care Research Centre - LEGACYen_UK
dc.contributor.affiliationHealth Sciences Highlanden_UK
dc.identifier.scopusid2-s2.0-84878031700en_UK
dc.identifier.wtid730756en_UK
dc.contributor.orcid0000-0003-2165-5770en_UK
dc.date.accepted2013-01-07en_UK
dcterms.dateAccepted2013-01-07en_UK
dc.date.filedepositdate2013-04-08en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorSchoultz, Mariyana|en_UK
local.rioxx.authorAtherton, Iain|en_UK
local.rioxx.authorHubbard, Gill|0000-0003-2165-5770en_UK
local.rioxx.authorWatson, Angus|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2013-04-08en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2013-04-08|en_UK
local.rioxx.filenameSchoultz et al_Systematic Reviews_2012.pdfen_UK
local.rioxx.filecount1en_UK
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