Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/11036
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Study protocol for BeWEL: The impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomas
Authors: Craigie, Angela
Caswell, Stephen
Paterson, Caron
Treweek, Shaun
Belch, Jill J F
Daly, Fergus
Rodger, Jackie
Thompson, Joyce
Kirk, Alison
Ludbrook, Anne
Stead, Martine
Wardle, Jane
Steele, Robert
Anderson, Annie S
Contact Email: martine.stead@stir.ac.uk
Issue Date: 25-Mar-2011
Publisher: BioMed Central Ltd
Citation: Craigie A, Caswell S, Paterson C, Treweek S, Belch JJF, Daly F, Rodger J, Thompson J, Kirk A, Ludbrook A, Stead M, Wardle J, Steele R & Anderson AS (2011) Study protocol for BeWEL: The impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomas, BMC Public Health, 11 (184).
Abstract: Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second highest cause of cancer death in the UK. Most cases occur in people over 50 years and CRC often co-exists with other lifestyle related disorders including obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). These diseases share risk factors related to the metabolic syndrome including large body size, abnormal lipids and markers of insulin resistance indicating common aetiological pathways. Methods/Design: This 3 year study will be a two-arm, multicentre, randomised controlled trial comparing the BeWEL lifestyle (diet, physical activity and behaviour change) programme against usual care. The pre-trial development will take 6 months and participants will be recruited over a 12 month period and undertake the intervention and follow up for 12 months (total 24 months recruitment and intervention implementation) with a further 6 months for data collection, analysis and interpretation. Four hundred and fifty two participants who have had a colorectal adenoma detected and removed (through the national colorectal screening programme) will provide 80% power to detect a weight loss of 7% over 12 months. Primary outcomes are changes in body weight and waist circumference. Secondary outcomes will include cardiovascular risk factors, psycho-social measures and intervention costs. Discussion: The results from this study will enhance the evidence base for lifestyle change in patients at higher risk of chronic disease including obesity related cancers.
Type: Journal Article
URI: http://hdl.handle.net/1893/11036
DOI Link: http://dx.doi.org/10.1186/1471-2458-11-184
Rights: © 2011 Craigie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Affiliation: University of Dundee
University of Dundee
University of Dundee
University of Dundee
University of Dundee
University of Dundee
NHS Tayside
NHS Tayside
University of Strathclyde
University of Aberdeen
Institute for Social Marketing
University College London
University of Dundee
University of Dundee

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