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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/10491
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dc.contributor.authorWright, Jamieen_UK
dc.contributor.authorClark, William McCaskillen_UK
dc.contributor.authorCairn, Jennifer Aen_UK
dc.contributor.authorPatterson, Alanen_UK
dc.contributor.authorCoates, Christopheren_UK
dc.contributor.authorNairn, Jacquelineen_UK
dc.date.accessioned2018-04-21T01:30:51Z-
dc.date.available2018-04-21T01:30:51Zen_UK
dc.date.issued2012-11en_UK
dc.identifier.urihttp://hdl.handle.net/1893/10491-
dc.description.abstractInhibitors of phenoloxidase are used routinely to characterise the structural and functional properties of phenoloxidases. Hemocyanin-derived phenoloxidase activity is also sensitive to standard phenoloxidase inhibitors. In this study, we characterise the effects of a number of phenoloxidase inhibitors on hemocyanin-derived phenoloxidase activity from the chelicerate, Limulus polyphemus. Both inhibition type and Ki values were similar to those observed for hemocyanin-derived phenoloxidase from another chelicerate, Eurypelma californicum. In addition, substrate inhibition was observed at concentrations above 2 mM dopamine. The conformation in which two of the inhibitors, namely tropolone and kojic acid, would bind near the Cu(II) centre of hemocyanin is proposed.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationWright J, Clark WM, Cairn JA, Patterson A, Coates C & Nairn J (2012) Effects of known phenoloxidase inhibitors on hemocyanin-derived phenoloxidase from Limulus polyphemus. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 163 (3-4), pp. 303-308. https://doi.org/10.1016/j.cbpb.2012.07.003en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectHemocyaninen_UK
dc.subjectPhenoloxidaseen_UK
dc.subjectHemocyanin-derived phenoloxidaseen_UK
dc.subjectKineticsen_UK
dc.subjectInhibitionen_UK
dc.titleEffects of known phenoloxidase inhibitors on hemocyanin-derived phenoloxidase from Limulus polyphemusen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Nairn4.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.cbpb.2012.07.003en_UK
dc.identifier.pmid22885403en_UK
dc.citation.jtitleComparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biologyen_UK
dc.citation.issn1096-4959en_UK
dc.citation.volume163en_UK
dc.citation.issue3-4en_UK
dc.citation.spage303en_UK
dc.citation.epage308en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailjn2@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationCampus Universidad Autonoma, Spainen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.identifier.isiWOS:000311178900005en_UK
dc.identifier.scopusid2-s2.0-84867903902en_UK
dc.identifier.wtid888735en_UK
dcterms.dateAccepted2012-11-30en_UK
dc.date.filedepositdate2013-01-16en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorWright, Jamie|en_UK
local.rioxx.authorClark, William McCaskill|en_UK
local.rioxx.authorCairn, Jennifer A|en_UK
local.rioxx.authorPatterson, Alan|en_UK
local.rioxx.authorCoates, Christopher|en_UK
local.rioxx.authorNairn, Jacqueline|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameNairn4.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1096-4959en_UK
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